Recombinant multi-species MKNK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MKNK2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
The Alternative Names of target: 2010016G11Rik,GPRK7,Gprk7,MAP kinase signal-integrating kinase 2 (MAPK signal-integrating kinase 2,MAP kinase-interacting serine/threonine-protein kinase 2,MKNK2,MNK2,Mknk2,Mnk2,Mnk2)

Target products collectionGo to MKNK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T99160-Ag-1/ GM-Tg-hg-T99160-Ag-2 Human MKNK2 protein Human
GM-Tg-rg-T99160-Ag-1/ GM-Tg-rg-T99160-Ag-2 Rat MKNK2 protein Rat
GM-Tg-mg-T99160-Ag-1/ GM-Tg-mg-T99160-Ag-2 Mouse MKNK2 protein Mouse
GM-Tg-cynog-T99160-Ag-1/ GM-Tg-cynog-T99160-Ag-2 Cynomolgus/Rhesus macaque MKNK2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T99160-Ag-1/ GM-Tg-felg-T99160-Ag-2 Feline MKNK2 protein Feline
GM-Tg-cang-T99160-Ag-1/ GM-Tg-cang-T99160-Ag-2 Canine MKNK2 protein Canine
GM-Tg-bovg-T99160-Ag-1/ GM-Tg-bovg-T99160-Ag-2 Bovine MKNK2 protein Bovine
GM-Tg-equg-T99160-Ag-1/ GM-Tg-equg-T99160-Ag-2 Equine MKNK2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T99160-Ag-1/ GM-Tg-hg-T99160-Ag-2; GM-Tg-rg-T99160-Ag-1/ GM-Tg-rg-T99160-Ag-2;
GM-Tg-mg-T99160-Ag-1/ GM-Tg-mg-T99160-Ag-2; GM-Tg-cynog-T99160-Ag-1/ GM-Tg-cynog-T99160-Ag-2;
GM-Tg-felg-T99160-Ag-1/ GM-Tg-felg-T99160-Ag-2; GM-Tg-cang-T99160-Ag-1/ GM-Tg-cang-T99160-Ag-2;
GM-Tg-bovg-T99160-Ag-1/ GM-Tg-bovg-T99160-Ag-2; GM-Tg-equg-T99160-Ag-1/ GM-Tg-equg-T99160-Ag-2
Products Name MKNK2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MKNK2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MKNK2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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