Recombinant multi-species TYMS/Thymidylate synthase protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TYMS/Thymidylate synthase protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
The Alternative Names of target: DKCD,HST422,TMS,TS,TSase,TYMS,Thymidylate synthase,Ts,Tyms

Target products collectionGo to TYMS/Thymidylate synthase products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T98397-Ag-1/ GM-Tg-hg-T98397-Ag-2 Human TYMS/Thymidylate synthase protein Human
GM-Tg-rg-T98397-Ag-1/ GM-Tg-rg-T98397-Ag-2 Rat TYMS/Thymidylate synthase protein Rat
GM-Tg-mg-T98397-Ag-1/ GM-Tg-mg-T98397-Ag-2 Mouse TYMS/Thymidylate synthase protein Mouse
GM-Tg-cynog-T98397-Ag-1/ GM-Tg-cynog-T98397-Ag-2 Cynomolgus/Rhesus macaque TYMS/Thymidylate synthase protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T98397-Ag-1/ GM-Tg-felg-T98397-Ag-2 Feline TYMS/Thymidylate synthase protein Feline
GM-Tg-cang-T98397-Ag-1/ GM-Tg-cang-T98397-Ag-2 Canine TYMS/Thymidylate synthase protein Canine
GM-Tg-bovg-T98397-Ag-1/ GM-Tg-bovg-T98397-Ag-2 Bovine TYMS/Thymidylate synthase protein Bovine
GM-Tg-equg-T98397-Ag-1/ GM-Tg-equg-T98397-Ag-2 Equine TYMS/Thymidylate synthase protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T98397-Ag-1/ GM-Tg-hg-T98397-Ag-2; GM-Tg-rg-T98397-Ag-1/ GM-Tg-rg-T98397-Ag-2;
GM-Tg-mg-T98397-Ag-1/ GM-Tg-mg-T98397-Ag-2; GM-Tg-cynog-T98397-Ag-1/ GM-Tg-cynog-T98397-Ag-2;
GM-Tg-felg-T98397-Ag-1/ GM-Tg-felg-T98397-Ag-2; GM-Tg-cang-T98397-Ag-1/ GM-Tg-cang-T98397-Ag-2;
GM-Tg-bovg-T98397-Ag-1/ GM-Tg-bovg-T98397-Ag-2; GM-Tg-equg-T98397-Ag-1/ GM-Tg-equg-T98397-Ag-2
Products Name TYMS/Thymidylate synthase protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TYMS/Thymidylate synthase
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TYMS/Thymidylate synthase protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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