Recombinant multi-species IL-12/IL-23 p40/IL12B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-12/IL-23 p40/IL12B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CLMF,CLMF2,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL-12,IL-12 subunit p40,IL-12.p40,IL-12B,IL-23 p40,IL12B,IL12p40,IMD28,IMD29,Il-12b,Il-12p40,Il12,Il12b,Il12p40,Interleukin-12 subunit beta,NK cell stimulatory factor chain 2 (NKSF2),NKSF,NKSF2,p40

Target products collectionGo to IL-12/IL-23 p40/IL12B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T95385-Ag-1/ GM-Tg-hg-T95385-Ag-2 Human IL-12/IL-23 p40/IL12B protein Human
GM-Tg-rg-T95385-Ag-1/ GM-Tg-rg-T95385-Ag-2 Rat IL-12/IL-23 p40/IL12B protein Rat
GM-Tg-mg-T95385-Ag-1/ GM-Tg-mg-T95385-Ag-2 Mouse IL-12/IL-23 p40/IL12B protein Mouse
GM-Tg-cynog-T95385-Ag-1/ GM-Tg-cynog-T95385-Ag-2 Cynomolgus/Rhesus macaque IL-12/IL-23 p40/IL12B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T95385-Ag-1/ GM-Tg-felg-T95385-Ag-2 Feline IL-12/IL-23 p40/IL12B protein Feline
GM-Tg-cang-T95385-Ag-1/ GM-Tg-cang-T95385-Ag-2 Canine IL-12/IL-23 p40/IL12B protein Canine
GM-Tg-bovg-T95385-Ag-1/ GM-Tg-bovg-T95385-Ag-2 Bovine IL-12/IL-23 p40/IL12B protein Bovine
GM-Tg-equg-T95385-Ag-1/ GM-Tg-equg-T95385-Ag-2 Equine IL-12/IL-23 p40/IL12B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T95385-Ag-1/ GM-Tg-hg-T95385-Ag-2; GM-Tg-rg-T95385-Ag-1/ GM-Tg-rg-T95385-Ag-2;
GM-Tg-mg-T95385-Ag-1/ GM-Tg-mg-T95385-Ag-2; GM-Tg-cynog-T95385-Ag-1/ GM-Tg-cynog-T95385-Ag-2;
GM-Tg-felg-T95385-Ag-1/ GM-Tg-felg-T95385-Ag-2; GM-Tg-cang-T95385-Ag-1/ GM-Tg-cang-T95385-Ag-2;
GM-Tg-bovg-T95385-Ag-1/ GM-Tg-bovg-T95385-Ag-2; GM-Tg-equg-T95385-Ag-1/ GM-Tg-equg-T95385-Ag-2
Products Name IL-12/IL-23 p40/IL12B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-12/IL-23 p40/IL12B
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-12/IL-23 p40/IL12B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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