Recombinant multi-species DYRK1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DYRK1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 2310043O08Rik,D16Ertd272e,D16Ertd493e,DYRK,DYRK1,DYRK1A,Dual specificity YAK1-related kinase,Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dyrk,Dyrk1a,Gm10783,HP86,MNB,MNBH,MRD7,Mnbh,Mp86,PSK47,Protein kinase minibrain homolog (MNBH,hMNB),mmb

Target products collectionGo to DYRK1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T92803-Ag-1/ GM-Tg-hg-T92803-Ag-2 Human DYRK1A protein Human
GM-Tg-rg-T92803-Ag-1/ GM-Tg-rg-T92803-Ag-2 Rat DYRK1A protein Rat
GM-Tg-mg-T92803-Ag-1/ GM-Tg-mg-T92803-Ag-2 Mouse DYRK1A protein Mouse
GM-Tg-cynog-T92803-Ag-1/ GM-Tg-cynog-T92803-Ag-2 Cynomolgus/Rhesus macaque DYRK1A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T92803-Ag-1/ GM-Tg-felg-T92803-Ag-2 Feline DYRK1A protein Feline
GM-Tg-cang-T92803-Ag-1/ GM-Tg-cang-T92803-Ag-2 Canine DYRK1A protein Canine
GM-Tg-bovg-T92803-Ag-1/ GM-Tg-bovg-T92803-Ag-2 Bovine DYRK1A protein Bovine
GM-Tg-equg-T92803-Ag-1/ GM-Tg-equg-T92803-Ag-2 Equine DYRK1A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T92803-Ag-1/ GM-Tg-hg-T92803-Ag-2; GM-Tg-rg-T92803-Ag-1/ GM-Tg-rg-T92803-Ag-2;
GM-Tg-mg-T92803-Ag-1/ GM-Tg-mg-T92803-Ag-2; GM-Tg-cynog-T92803-Ag-1/ GM-Tg-cynog-T92803-Ag-2;
GM-Tg-felg-T92803-Ag-1/ GM-Tg-felg-T92803-Ag-2; GM-Tg-cang-T92803-Ag-1/ GM-Tg-cang-T92803-Ag-2;
GM-Tg-bovg-T92803-Ag-1/ GM-Tg-bovg-T92803-Ag-2; GM-Tg-equg-T92803-Ag-1/ GM-Tg-equg-T92803-Ag-2
Products Name DYRK1A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DYRK1A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DYRK1A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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