Recombinant multi-species CFI protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CFI protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]
The Alternative Names of target: AHUS3,ARMD13,C3B/C4B inactivator,C3BINA,C3b-INA,CFI,Cfi,Complement factor I,FI,IF,KAF

Target products collectionGo to CFI products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T92750-Ag-1/ GM-Tg-hg-T92750-Ag-2 Human CFI protein Human
GM-Tg-rg-T92750-Ag-1/ GM-Tg-rg-T92750-Ag-2 Rat CFI protein Rat
GM-Tg-mg-T92750-Ag-1/ GM-Tg-mg-T92750-Ag-2 Mouse CFI protein Mouse
GM-Tg-cynog-T92750-Ag-1/ GM-Tg-cynog-T92750-Ag-2 Cynomolgus/Rhesus macaque CFI protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T92750-Ag-1/ GM-Tg-felg-T92750-Ag-2 Feline CFI protein Feline
GM-Tg-cang-T92750-Ag-1/ GM-Tg-cang-T92750-Ag-2 Canine CFI protein Canine
GM-Tg-bovg-T92750-Ag-1/ GM-Tg-bovg-T92750-Ag-2 Bovine CFI protein Bovine
GM-Tg-equg-T92750-Ag-1/ GM-Tg-equg-T92750-Ag-2 Equine CFI protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T92750-Ag-1/ GM-Tg-hg-T92750-Ag-2; GM-Tg-rg-T92750-Ag-1/ GM-Tg-rg-T92750-Ag-2;
GM-Tg-mg-T92750-Ag-1/ GM-Tg-mg-T92750-Ag-2; GM-Tg-cynog-T92750-Ag-1/ GM-Tg-cynog-T92750-Ag-2;
GM-Tg-felg-T92750-Ag-1/ GM-Tg-felg-T92750-Ag-2; GM-Tg-cang-T92750-Ag-1/ GM-Tg-cang-T92750-Ag-2;
GM-Tg-bovg-T92750-Ag-1/ GM-Tg-bovg-T92750-Ag-2; GM-Tg-equg-T92750-Ag-1/ GM-Tg-equg-T92750-Ag-2
Products Name CFI protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CFI
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CFI protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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