Recombinant multi-species ER/ESR1/ESR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ER/ESR1/ESR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]
The Alternative Names of target: ER,ER-alpha,ERALPHA,ERa,ERalpha,ESR,ESR1,ESRA,ESTRR,Era,Esr,Esr1,Estr,Estra,Estradiol receptor,Estrogen receptor,NR3A1,Nr3a1,Nuclear receptor subfamily 3 group A member 1,RNESTROR

Target products collectionGo to ER/ESR1/ESR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T89534-Ag-1/ GM-Tg-hg-T89534-Ag-2 Human ER/ESR1/ESR protein Human
GM-Tg-rg-T89534-Ag-1/ GM-Tg-rg-T89534-Ag-2 Rat ER/ESR1/ESR protein Rat
GM-Tg-mg-T89534-Ag-1/ GM-Tg-mg-T89534-Ag-2 Mouse ER/ESR1/ESR protein Mouse
GM-Tg-cynog-T89534-Ag-1/ GM-Tg-cynog-T89534-Ag-2 Cynomolgus/Rhesus macaque ER/ESR1/ESR protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T89534-Ag-1/ GM-Tg-felg-T89534-Ag-2 Feline ER/ESR1/ESR protein Feline
GM-Tg-cang-T89534-Ag-1/ GM-Tg-cang-T89534-Ag-2 Canine ER/ESR1/ESR protein Canine
GM-Tg-bovg-T89534-Ag-1/ GM-Tg-bovg-T89534-Ag-2 Bovine ER/ESR1/ESR protein Bovine
GM-Tg-equg-T89534-Ag-1/ GM-Tg-equg-T89534-Ag-2 Equine ER/ESR1/ESR protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T89534-Ag-1/ GM-Tg-hg-T89534-Ag-2; GM-Tg-rg-T89534-Ag-1/ GM-Tg-rg-T89534-Ag-2;
GM-Tg-mg-T89534-Ag-1/ GM-Tg-mg-T89534-Ag-2; GM-Tg-cynog-T89534-Ag-1/ GM-Tg-cynog-T89534-Ag-2;
GM-Tg-felg-T89534-Ag-1/ GM-Tg-felg-T89534-Ag-2; GM-Tg-cang-T89534-Ag-1/ GM-Tg-cang-T89534-Ag-2;
GM-Tg-bovg-T89534-Ag-1/ GM-Tg-bovg-T89534-Ag-2; GM-Tg-equg-T89534-Ag-1/ GM-Tg-equg-T89534-Ag-2
Products Name ER/ESR1/ESR protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ER/ESR1/ESR
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ER/ESR1/ESR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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