Recombinant multi-species UBE3A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UBE3A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 4732496B02,5830462N02Rik,A130086L21Rik,ANCR,AS,E6-AP,E6AP ubiquitin-protein ligase,EPVE6AP,HECT-type ubiquitin transferase E3A,HPVE6A,Hpve6a,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,PIX1,Renal carcinoma antigen NY-REN-54,UBE3A,UBE3A-V1,UBE3A-V2,UBE3A-V3,UBE3A-V4,UBE3A-V5,Ube3a,Ubiquitin-protein ligase E3A

Target products collectionGo to UBE3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T87376-Ag-1/ GM-Tg-hg-T87376-Ag-2 Human UBE3A protein Human
GM-Tg-rg-T87376-Ag-1/ GM-Tg-rg-T87376-Ag-2 Rat UBE3A protein Rat
GM-Tg-mg-T87376-Ag-1/ GM-Tg-mg-T87376-Ag-2 Mouse UBE3A protein Mouse
GM-Tg-cynog-T87376-Ag-1/ GM-Tg-cynog-T87376-Ag-2 Cynomolgus/Rhesus macaque UBE3A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T87376-Ag-1/ GM-Tg-felg-T87376-Ag-2 Feline UBE3A protein Feline
GM-Tg-cang-T87376-Ag-1/ GM-Tg-cang-T87376-Ag-2 Canine UBE3A protein Canine
GM-Tg-bovg-T87376-Ag-1/ GM-Tg-bovg-T87376-Ag-2 Bovine UBE3A protein Bovine
GM-Tg-equg-T87376-Ag-1/ GM-Tg-equg-T87376-Ag-2 Equine UBE3A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T87376-Ag-1/ GM-Tg-hg-T87376-Ag-2; GM-Tg-rg-T87376-Ag-1/ GM-Tg-rg-T87376-Ag-2;
GM-Tg-mg-T87376-Ag-1/ GM-Tg-mg-T87376-Ag-2; GM-Tg-cynog-T87376-Ag-1/ GM-Tg-cynog-T87376-Ag-2;
GM-Tg-felg-T87376-Ag-1/ GM-Tg-felg-T87376-Ag-2; GM-Tg-cang-T87376-Ag-1/ GM-Tg-cang-T87376-Ag-2;
GM-Tg-bovg-T87376-Ag-1/ GM-Tg-bovg-T87376-Ag-2; GM-Tg-equg-T87376-Ag-1/ GM-Tg-equg-T87376-Ag-2
Products Name UBE3A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name UBE3A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UBE3A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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