Recombinant multi-species GCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
The Alternative Names of target: FGQTL3,GCK,GK,GLK,GLUKA,Gck,Gk,Gls006,Glucokinase,HHF3,HK4,HKIV,HXKP,Hexokinase type IV (HK IV),Hexokinase-4,Hexokinase-D,Hlb62,LGLK,MODY2,PNDM1,RNGK2

Target products collectionGo to GCK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T87166-Ag-1/ GM-Tg-hg-T87166-Ag-2 Human GCK protein Human
GM-Tg-rg-T87166-Ag-1/ GM-Tg-rg-T87166-Ag-2 Rat GCK protein Rat
GM-Tg-mg-T87166-Ag-1/ GM-Tg-mg-T87166-Ag-2 Mouse GCK protein Mouse
GM-Tg-cynog-T87166-Ag-1/ GM-Tg-cynog-T87166-Ag-2 Cynomolgus/Rhesus macaque GCK protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T87166-Ag-1/ GM-Tg-felg-T87166-Ag-2 Feline GCK protein Feline
GM-Tg-cang-T87166-Ag-1/ GM-Tg-cang-T87166-Ag-2 Canine GCK protein Canine
GM-Tg-bovg-T87166-Ag-1/ GM-Tg-bovg-T87166-Ag-2 Bovine GCK protein Bovine
GM-Tg-equg-T87166-Ag-1/ GM-Tg-equg-T87166-Ag-2 Equine GCK protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T87166-Ag-1/ GM-Tg-hg-T87166-Ag-2; GM-Tg-rg-T87166-Ag-1/ GM-Tg-rg-T87166-Ag-2;
GM-Tg-mg-T87166-Ag-1/ GM-Tg-mg-T87166-Ag-2; GM-Tg-cynog-T87166-Ag-1/ GM-Tg-cynog-T87166-Ag-2;
GM-Tg-felg-T87166-Ag-1/ GM-Tg-felg-T87166-Ag-2; GM-Tg-cang-T87166-Ag-1/ GM-Tg-cang-T87166-Ag-2;
GM-Tg-bovg-T87166-Ag-1/ GM-Tg-bovg-T87166-Ag-2; GM-Tg-equg-T87166-Ag-1/ GM-Tg-equg-T87166-Ag-2
Products Name GCK protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GCK
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GCK protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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