Recombinant multi-species CDK4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
The Alternative Names of target: CDK4,CMM3,Cdk4,Cell division protein kinase 4,Crk3,Cyclin-dependent kinase 4,PSK-J3

Target products collectionGo to CDK4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T85799-Ag-1/ GM-Tg-hg-T85799-Ag-2 Human CDK4 protein Human
GM-Tg-rg-T85799-Ag-1/ GM-Tg-rg-T85799-Ag-2 Rat CDK4 protein Rat
GM-Tg-mg-T85799-Ag-1/ GM-Tg-mg-T85799-Ag-2 Mouse CDK4 protein Mouse
GM-Tg-cynog-T85799-Ag-1/ GM-Tg-cynog-T85799-Ag-2 Cynomolgus/Rhesus macaque CDK4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T85799-Ag-1/ GM-Tg-felg-T85799-Ag-2 Feline CDK4 protein Feline
GM-Tg-cang-T85799-Ag-1/ GM-Tg-cang-T85799-Ag-2 Canine CDK4 protein Canine
GM-Tg-bovg-T85799-Ag-1/ GM-Tg-bovg-T85799-Ag-2 Bovine CDK4 protein Bovine
GM-Tg-equg-T85799-Ag-1/ GM-Tg-equg-T85799-Ag-2 Equine CDK4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T85799-Ag-1/ GM-Tg-hg-T85799-Ag-2; GM-Tg-rg-T85799-Ag-1/ GM-Tg-rg-T85799-Ag-2;
GM-Tg-mg-T85799-Ag-1/ GM-Tg-mg-T85799-Ag-2; GM-Tg-cynog-T85799-Ag-1/ GM-Tg-cynog-T85799-Ag-2;
GM-Tg-felg-T85799-Ag-1/ GM-Tg-felg-T85799-Ag-2; GM-Tg-cang-T85799-Ag-1/ GM-Tg-cang-T85799-Ag-2;
GM-Tg-bovg-T85799-Ag-1/ GM-Tg-bovg-T85799-Ag-2; GM-Tg-equg-T85799-Ag-1/ GM-Tg-equg-T85799-Ag-2
Products Name CDK4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CDK4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDK4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.