Recombinant multi-species TOP2B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TOP2B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
The Alternative Names of target: BILU,D230016L12Rik,DNA topoisomerase 2-beta,DNA topoisomerase II,TOP2B,TOPIIB,Top-2,Top2b,beta isozyme,top2beta

Target products collectionGo to TOP2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T85733-Ag-1/ GM-Tg-hg-T85733-Ag-2 Human TOP2B protein Human
GM-Tg-rg-T85733-Ag-1/ GM-Tg-rg-T85733-Ag-2 Rat TOP2B protein Rat
GM-Tg-mg-T85733-Ag-1/ GM-Tg-mg-T85733-Ag-2 Mouse TOP2B protein Mouse
GM-Tg-cynog-T85733-Ag-1/ GM-Tg-cynog-T85733-Ag-2 Cynomolgus/Rhesus macaque TOP2B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T85733-Ag-1/ GM-Tg-felg-T85733-Ag-2 Feline TOP2B protein Feline
GM-Tg-cang-T85733-Ag-1/ GM-Tg-cang-T85733-Ag-2 Canine TOP2B protein Canine
GM-Tg-bovg-T85733-Ag-1/ GM-Tg-bovg-T85733-Ag-2 Bovine TOP2B protein Bovine
GM-Tg-equg-T85733-Ag-1/ GM-Tg-equg-T85733-Ag-2 Equine TOP2B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T85733-Ag-1/ GM-Tg-hg-T85733-Ag-2; GM-Tg-rg-T85733-Ag-1/ GM-Tg-rg-T85733-Ag-2;
GM-Tg-mg-T85733-Ag-1/ GM-Tg-mg-T85733-Ag-2; GM-Tg-cynog-T85733-Ag-1/ GM-Tg-cynog-T85733-Ag-2;
GM-Tg-felg-T85733-Ag-1/ GM-Tg-felg-T85733-Ag-2; GM-Tg-cang-T85733-Ag-1/ GM-Tg-cang-T85733-Ag-2;
GM-Tg-bovg-T85733-Ag-1/ GM-Tg-bovg-T85733-Ag-2; GM-Tg-equg-T85733-Ag-1/ GM-Tg-equg-T85733-Ag-2
Products Name TOP2B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TOP2B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TOP2B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.