Recombinant multi-species DNase I/DNASE1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNase I/DNASE1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
The Alternative Names of target: DNASE1,DNL1,DNase I,DNaseI,DRNI,Deoxyribonuclease I (DNase I),Deoxyribonuclease-1,Dnase1,Dnl1

Target products collectionGo to DNase I/DNASE1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T85223-Ag-1/ GM-Tg-hg-T85223-Ag-2 Human DNase I/DNASE1 protein Human
GM-Tg-rg-T85223-Ag-1/ GM-Tg-rg-T85223-Ag-2 Rat DNase I/DNASE1 protein Rat
GM-Tg-mg-T85223-Ag-1/ GM-Tg-mg-T85223-Ag-2 Mouse DNase I/DNASE1 protein Mouse
GM-Tg-cynog-T85223-Ag-1/ GM-Tg-cynog-T85223-Ag-2 Cynomolgus/Rhesus macaque DNase I/DNASE1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T85223-Ag-1/ GM-Tg-felg-T85223-Ag-2 Feline DNase I/DNASE1 protein Feline
GM-Tg-cang-T85223-Ag-1/ GM-Tg-cang-T85223-Ag-2 Canine DNase I/DNASE1 protein Canine
GM-Tg-bovg-T85223-Ag-1/ GM-Tg-bovg-T85223-Ag-2 Bovine DNase I/DNASE1 protein Bovine
GM-Tg-equg-T85223-Ag-1/ GM-Tg-equg-T85223-Ag-2 Equine DNase I/DNASE1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T85223-Ag-1/ GM-Tg-hg-T85223-Ag-2; GM-Tg-rg-T85223-Ag-1/ GM-Tg-rg-T85223-Ag-2;
GM-Tg-mg-T85223-Ag-1/ GM-Tg-mg-T85223-Ag-2; GM-Tg-cynog-T85223-Ag-1/ GM-Tg-cynog-T85223-Ag-2;
GM-Tg-felg-T85223-Ag-1/ GM-Tg-felg-T85223-Ag-2; GM-Tg-cang-T85223-Ag-1/ GM-Tg-cang-T85223-Ag-2;
GM-Tg-bovg-T85223-Ag-1/ GM-Tg-bovg-T85223-Ag-2; GM-Tg-equg-T85223-Ag-1/ GM-Tg-equg-T85223-Ag-2
Products Name DNase I/DNASE1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DNase I/DNASE1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DNase I/DNASE1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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