Recombinant multi-species CLCF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLCF1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
The Alternative Names of target: B-cell-stimulating factor 3 (BSF-3),BSF-3,BSF3,Bsf3,CISS2,CLC,CLCF1,Cardiotrophin-like cytokine factor 1,Clc,Clcf1,NNT-1,NNT1,NR6,Novel neurotrophin-1 (NNT-1)

Target products collectionGo to CLCF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T84019-Ag-1/ GM-Tg-hg-T84019-Ag-2 Human CLCF1 protein Human
GM-Tg-rg-T84019-Ag-1/ GM-Tg-rg-T84019-Ag-2 Rat CLCF1 protein Rat
GM-Tg-mg-T84019-Ag-1/ GM-Tg-mg-T84019-Ag-2 Mouse CLCF1 protein Mouse
GM-Tg-cynog-T84019-Ag-1/ GM-Tg-cynog-T84019-Ag-2 Cynomolgus/Rhesus macaque CLCF1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T84019-Ag-1/ GM-Tg-felg-T84019-Ag-2 Feline CLCF1 protein Feline
GM-Tg-cang-T84019-Ag-1/ GM-Tg-cang-T84019-Ag-2 Canine CLCF1 protein Canine
GM-Tg-bovg-T84019-Ag-1/ GM-Tg-bovg-T84019-Ag-2 Bovine CLCF1 protein Bovine
GM-Tg-equg-T84019-Ag-1/ GM-Tg-equg-T84019-Ag-2 Equine CLCF1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T84019-Ag-1/ GM-Tg-hg-T84019-Ag-2; GM-Tg-rg-T84019-Ag-1/ GM-Tg-rg-T84019-Ag-2;
GM-Tg-mg-T84019-Ag-1/ GM-Tg-mg-T84019-Ag-2; GM-Tg-cynog-T84019-Ag-1/ GM-Tg-cynog-T84019-Ag-2;
GM-Tg-felg-T84019-Ag-1/ GM-Tg-felg-T84019-Ag-2; GM-Tg-cang-T84019-Ag-1/ GM-Tg-cang-T84019-Ag-2;
GM-Tg-bovg-T84019-Ag-1/ GM-Tg-bovg-T84019-Ag-2; GM-Tg-equg-T84019-Ag-1/ GM-Tg-equg-T84019-Ag-2
Products Name CLCF1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CLCF1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLCF1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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