Recombinant multi-species INS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine INS protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
The Alternative Names of target: CP-II,IDDM,IDDM1,IDDM2,ILPR,INS,IRDN,Ins-2,Ins2,InsII,Insulin,MODY10,Mody,Mody4,PNDM4

Target products collectionGo to INS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T82841-Ag-1/ GM-Tg-hg-T82841-Ag-2 Human INS protein Human
GM-Tg-rg-T82841-Ag-1/ GM-Tg-rg-T82841-Ag-2 Rat INS protein Rat
GM-Tg-mg-T82841-Ag-1/ GM-Tg-mg-T82841-Ag-2 Mouse INS protein Mouse
GM-Tg-cynog-T82841-Ag-1/ GM-Tg-cynog-T82841-Ag-2 Cynomolgus/Rhesus macaque INS protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T82841-Ag-1/ GM-Tg-felg-T82841-Ag-2 Feline INS protein Feline
GM-Tg-cang-T82841-Ag-1/ GM-Tg-cang-T82841-Ag-2 Canine INS protein Canine
GM-Tg-bovg-T82841-Ag-1/ GM-Tg-bovg-T82841-Ag-2 Bovine INS protein Bovine
GM-Tg-equg-T82841-Ag-1/ GM-Tg-equg-T82841-Ag-2 Equine INS protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T82841-Ag-1/ GM-Tg-hg-T82841-Ag-2; GM-Tg-rg-T82841-Ag-1/ GM-Tg-rg-T82841-Ag-2;
GM-Tg-mg-T82841-Ag-1/ GM-Tg-mg-T82841-Ag-2; GM-Tg-cynog-T82841-Ag-1/ GM-Tg-cynog-T82841-Ag-2;
GM-Tg-felg-T82841-Ag-1/ GM-Tg-felg-T82841-Ag-2; GM-Tg-cang-T82841-Ag-1/ GM-Tg-cang-T82841-Ag-2;
GM-Tg-bovg-T82841-Ag-1/ GM-Tg-bovg-T82841-Ag-2; GM-Tg-equg-T82841-Ag-1/ GM-Tg-equg-T82841-Ag-2
Products Name INS protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name INS
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine INS protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.