Recombinant multi-species PXR/NR1I2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PXR/NR1I2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
The Alternative Names of target: PXR, NR1I2,Nuclear receptor subfamily 1 group I member 2,Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor (SXR),BXR,PAR,PRR,PXR,SAR,SXR,ONR1,PAR1,PAR2,PARq

Target products collectionGo to PXR/NR1I2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T82702-Ab-1/ GM-Tg-hg-T82702-Ab-2 Human PXR/NR1I2 protein Human
GM-Tg-rg-T82702-Ab-1/ GM-Tg-rg-T82702-Ab-2 Rat PXR/NR1I2 protein Rat
GM-Tg-mg-T82702-Ab-1/ GM-Tg-mg-T82702-Ab-2 Mouse PXR/NR1I2 protein Mouse
GM-Tg-cynog-T82702-Ab-1/ GM-Tg-cynog-T82702-Ab-2 Cynomolgus/Rhesus macaque PXR/NR1I2 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T82702-Ab-1/ GM-Tg-felg-T82702-Ab-2 Feline PXR/NR1I2 protein Feline
GM-Tg-cang-T82702-Ab-1/ GM-Tg-cang-T82702-Ab-2 Canine PXR/NR1I2 protein Canine
GM-Tg-bovg-T82702-Ab-1/ GM-Tg-bovg-T82702-Ab-2 Bovine PXR/NR1I2 protein Bovine
GM-Tg-equg-T82702-Ab-1/ GM-Tg-equg-T82702-Ab-2 Equine PXR/NR1I2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T82702-Ab-1/ GM-Tg-hg-T82702-Ab-2; GM-Tg-rg-T82702-Ab-1/ GM-Tg-rg-T82702-Ab-2;
GM-Tg-mg-T82702-Ab-1/ GM-Tg-mg-T82702-Ab-2; GM-Tg-cynog-T82702-Ab-1/ GM-Tg-cynog-T82702-Ab-2;
GM-Tg-felg-T82702-Ab-1/ GM-Tg-felg-T82702-Ab-2; GM-Tg-cang-T82702-Ab-1/ GM-Tg-cang-T82702-Ab-2;
GM-Tg-bovg-T82702-Ab-1/ GM-Tg-bovg-T82702-Ab-2; GM-Tg-equg-T82702-Ab-1/ GM-Tg-equg-T82702-Ab-2
Products Name PXR/NR1I2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PXR/NR1I2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PXR/NR1I2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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