Recombinant multi-species IDE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
The Alternative Names of target: 1300012G03Rik,4833415K22Rik,Abeta-degrading protease,IDE,INSDEGM,INSULYSIN,Ide,Insulin protease (Insulinase),Insulin-degrading enzyme,Insulysin

Target products collectionGo to IDE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T81900-Ag-1/ GM-Tg-hg-T81900-Ag-2 Human IDE protein Human
GM-Tg-rg-T81900-Ag-1/ GM-Tg-rg-T81900-Ag-2 Rat IDE protein Rat
GM-Tg-mg-T81900-Ag-1/ GM-Tg-mg-T81900-Ag-2 Mouse IDE protein Mouse
GM-Tg-cynog-T81900-Ag-1/ GM-Tg-cynog-T81900-Ag-2 Cynomolgus/Rhesus macaque IDE protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T81900-Ag-1/ GM-Tg-felg-T81900-Ag-2 Feline IDE protein Feline
GM-Tg-cang-T81900-Ag-1/ GM-Tg-cang-T81900-Ag-2 Canine IDE protein Canine
GM-Tg-bovg-T81900-Ag-1/ GM-Tg-bovg-T81900-Ag-2 Bovine IDE protein Bovine
GM-Tg-equg-T81900-Ag-1/ GM-Tg-equg-T81900-Ag-2 Equine IDE protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T81900-Ag-1/ GM-Tg-hg-T81900-Ag-2; GM-Tg-rg-T81900-Ag-1/ GM-Tg-rg-T81900-Ag-2;
GM-Tg-mg-T81900-Ag-1/ GM-Tg-mg-T81900-Ag-2; GM-Tg-cynog-T81900-Ag-1/ GM-Tg-cynog-T81900-Ag-2;
GM-Tg-felg-T81900-Ag-1/ GM-Tg-felg-T81900-Ag-2; GM-Tg-cang-T81900-Ag-1/ GM-Tg-cang-T81900-Ag-2;
GM-Tg-bovg-T81900-Ag-1/ GM-Tg-bovg-T81900-Ag-2; GM-Tg-equg-T81900-Ag-1/ GM-Tg-equg-T81900-Ag-2
Products Name IDE protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IDE
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.