Recombinant multi-species ADAMTS4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ADAMTS4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
The Alternative Names of target: A disintegrin and metalloproteinase with thrombospondin motifs 4,ADAM-TS 4,ADAM-TS4,ADAMTS-2,ADAMTS-4,ADAMTS4,ADMP-1,Adamts4,Aggrecanase-1

Target products collectionGo to ADAMTS4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T79570-Ag-1/ GM-Tg-hg-T79570-Ag-2 Human ADAMTS4 protein Human
GM-Tg-rg-T79570-Ag-1/ GM-Tg-rg-T79570-Ag-2 Rat ADAMTS4 protein Rat
GM-Tg-mg-T79570-Ag-1/ GM-Tg-mg-T79570-Ag-2 Mouse ADAMTS4 protein Mouse
GM-Tg-cynog-T79570-Ag-1/ GM-Tg-cynog-T79570-Ag-2 Cynomolgus/Rhesus macaque ADAMTS4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T79570-Ag-1/ GM-Tg-felg-T79570-Ag-2 Feline ADAMTS4 protein Feline
GM-Tg-cang-T79570-Ag-1/ GM-Tg-cang-T79570-Ag-2 Canine ADAMTS4 protein Canine
GM-Tg-bovg-T79570-Ag-1/ GM-Tg-bovg-T79570-Ag-2 Bovine ADAMTS4 protein Bovine
GM-Tg-equg-T79570-Ag-1/ GM-Tg-equg-T79570-Ag-2 Equine ADAMTS4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T79570-Ag-1/ GM-Tg-hg-T79570-Ag-2; GM-Tg-rg-T79570-Ag-1/ GM-Tg-rg-T79570-Ag-2;
GM-Tg-mg-T79570-Ag-1/ GM-Tg-mg-T79570-Ag-2; GM-Tg-cynog-T79570-Ag-1/ GM-Tg-cynog-T79570-Ag-2;
GM-Tg-felg-T79570-Ag-1/ GM-Tg-felg-T79570-Ag-2; GM-Tg-cang-T79570-Ag-1/ GM-Tg-cang-T79570-Ag-2;
GM-Tg-bovg-T79570-Ag-1/ GM-Tg-bovg-T79570-Ag-2; GM-Tg-equg-T79570-Ag-1/ GM-Tg-equg-T79570-Ag-2
Products Name ADAMTS4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ADAMTS4
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ADAMTS4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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