Recombinant multi-species GDNF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GDNF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
The Alternative Names of target: ATF,ATF1,ATF2,Astrocyte-derived trophic factor (ATF),GDNF,Gdnf,Glial cell line-derived neurotrophic factor,HFB1-GDNF,HSCR3,gndf,hGDNF

Target products collectionGo to GDNF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T79160-Ag-1/ GM-Tg-hg-T79160-Ag-2 Human GDNF protein Human
GM-Tg-rg-T79160-Ag-1/ GM-Tg-rg-T79160-Ag-2 Rat GDNF protein Rat
GM-Tg-mg-T79160-Ag-1/ GM-Tg-mg-T79160-Ag-2 Mouse GDNF protein Mouse
GM-Tg-cynog-T79160-Ag-1/ GM-Tg-cynog-T79160-Ag-2 Cynomolgus/Rhesus macaque GDNF protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T79160-Ag-1/ GM-Tg-felg-T79160-Ag-2 Feline GDNF protein Feline
GM-Tg-cang-T79160-Ag-1/ GM-Tg-cang-T79160-Ag-2 Canine GDNF protein Canine
GM-Tg-bovg-T79160-Ag-1/ GM-Tg-bovg-T79160-Ag-2 Bovine GDNF protein Bovine
GM-Tg-equg-T79160-Ag-1/ GM-Tg-equg-T79160-Ag-2 Equine GDNF protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T79160-Ag-1/ GM-Tg-hg-T79160-Ag-2; GM-Tg-rg-T79160-Ag-1/ GM-Tg-rg-T79160-Ag-2;
GM-Tg-mg-T79160-Ag-1/ GM-Tg-mg-T79160-Ag-2; GM-Tg-cynog-T79160-Ag-1/ GM-Tg-cynog-T79160-Ag-2;
GM-Tg-felg-T79160-Ag-1/ GM-Tg-felg-T79160-Ag-2; GM-Tg-cang-T79160-Ag-1/ GM-Tg-cang-T79160-Ag-2;
GM-Tg-bovg-T79160-Ag-1/ GM-Tg-bovg-T79160-Ag-2; GM-Tg-equg-T79160-Ag-1/ GM-Tg-equg-T79160-Ag-2
Products Name GDNF protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GDNF
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GDNF protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.