Recombinant multi-species NISCH/IR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NISCH/IR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
The Alternative Names of target: NISCH, IR1,Nischarin,Imidazoline receptor 1 (I-1, IR1), Imidazoline receptor antisera-selected protein (hIRAS), Imidazoline-1 receptor (I1R), Imidazoline-1 receptor candidate protein (I-1 receptor candidate protein, I1R candidate protein),I-1,IR1,IRAS,hIRAS

Target products collectionGo to NISCH/IR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T78943-Ab-1/ GM-Tg-hg-T78943-Ab-2 Human NISCH/IR1 protein Human
GM-Tg-rg-T78943-Ab-1/ GM-Tg-rg-T78943-Ab-2 Rat NISCH/IR1 protein Rat
GM-Tg-mg-T78943-Ab-1/ GM-Tg-mg-T78943-Ab-2 Mouse NISCH/IR1 protein Mouse
GM-Tg-cynog-T78943-Ab-1/ GM-Tg-cynog-T78943-Ab-2 Cynomolgus/Rhesus macaque NISCH/IR1 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T78943-Ab-1/ GM-Tg-felg-T78943-Ab-2 Feline NISCH/IR1 protein Feline
GM-Tg-cang-T78943-Ab-1/ GM-Tg-cang-T78943-Ab-2 Canine NISCH/IR1 protein Canine
GM-Tg-bovg-T78943-Ab-1/ GM-Tg-bovg-T78943-Ab-2 Bovine NISCH/IR1 protein Bovine
GM-Tg-equg-T78943-Ab-1/ GM-Tg-equg-T78943-Ab-2 Equine NISCH/IR1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T78943-Ab-1/ GM-Tg-hg-T78943-Ab-2; GM-Tg-rg-T78943-Ab-1/ GM-Tg-rg-T78943-Ab-2;
GM-Tg-mg-T78943-Ab-1/ GM-Tg-mg-T78943-Ab-2; GM-Tg-cynog-T78943-Ab-1/ GM-Tg-cynog-T78943-Ab-2;
GM-Tg-felg-T78943-Ab-1/ GM-Tg-felg-T78943-Ab-2; GM-Tg-cang-T78943-Ab-1/ GM-Tg-cang-T78943-Ab-2;
GM-Tg-bovg-T78943-Ab-1/ GM-Tg-bovg-T78943-Ab-2; GM-Tg-equg-T78943-Ab-1/ GM-Tg-equg-T78943-Ab-2
Products Name NISCH/IR1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NISCH/IR1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NISCH/IR1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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