Recombinant multi-species LAMC2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LAMC2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]
The Alternative Names of target: B2T,BM600,CSF,Cell-scattering factor 140 kDa subunit (CSF 140 kDa subunit),EBR2,EBR2A,Epiligrin subunit gamma,JEB3A,JEB3B,Kalinin subunit gamma,Kalinin/nicein/epiligrin 100 kDa subunit,LAMB2T,LAMC2,LAMNB2,Ladsin 140 kDa subunit,Lamc2,Laminin B2t chain,Laminin subunit gamma-2,Laminin-5 subunit gamma,Large adhesive scatter factor 140 kDa subunit,Nicein subunit gamma

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T75613-Ag-1/ GM-Tg-hg-T75613-Ag-2 Human LAMC2 protein Human
GM-Tg-rg-T75613-Ag-1/ GM-Tg-rg-T75613-Ag-2 Rat LAMC2 protein Rat
GM-Tg-mg-T75613-Ag-1/ GM-Tg-mg-T75613-Ag-2 Mouse LAMC2 protein Mouse
GM-Tg-cynog-T75613-Ag-1/ GM-Tg-cynog-T75613-Ag-2 Cynomolgus/Rhesus macaque LAMC2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T75613-Ag-1/ GM-Tg-felg-T75613-Ag-2 Feline LAMC2 protein Feline
GM-Tg-cang-T75613-Ag-1/ GM-Tg-cang-T75613-Ag-2 Canine LAMC2 protein Canine
GM-Tg-bovg-T75613-Ag-1/ GM-Tg-bovg-T75613-Ag-2 Bovine LAMC2 protein Bovine
GM-Tg-equg-T75613-Ag-1/ GM-Tg-equg-T75613-Ag-2 Equine LAMC2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T75613-Ag-1/ GM-Tg-hg-T75613-Ag-2; GM-Tg-rg-T75613-Ag-1/ GM-Tg-rg-T75613-Ag-2;
GM-Tg-mg-T75613-Ag-1/ GM-Tg-mg-T75613-Ag-2; GM-Tg-cynog-T75613-Ag-1/ GM-Tg-cynog-T75613-Ag-2;
GM-Tg-felg-T75613-Ag-1/ GM-Tg-felg-T75613-Ag-2; GM-Tg-cang-T75613-Ag-1/ GM-Tg-cang-T75613-Ag-2;
GM-Tg-bovg-T75613-Ag-1/ GM-Tg-bovg-T75613-Ag-2; GM-Tg-equg-T75613-Ag-1/ GM-Tg-equg-T75613-Ag-2
Products Name LAMC2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LAMC2
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LAMC2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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