Recombinant multi-species SMN-Exon7/SMN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMN-Exon7/SMN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2014]
The Alternative Names of target: SMN-Exon7, SMN1,Survival motor neuron protein,Component of gems 1, Gemin-1,SMA,SMN,SMA1,SMA2,SMA3,SMA4,SMA@,SMNT,BCD541,GEMIN1,TDRD16A,T-BCD541

Target products collectionGo to SMN-Exon7/SMN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T71907-Ab-1/ GM-Tg-hg-T71907-Ab-2 Human SMN-Exon7/SMN1 protein Human
GM-Tg-rg-T71907-Ab-1/ GM-Tg-rg-T71907-Ab-2 Rat SMN-Exon7/SMN1 protein Rat
GM-Tg-mg-T71907-Ab-1/ GM-Tg-mg-T71907-Ab-2 Mouse SMN-Exon7/SMN1 protein Mouse
GM-Tg-cynog-T71907-Ab-1/ GM-Tg-cynog-T71907-Ab-2 Cynomolgus/Rhesus macaque SMN-Exon7/SMN1 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T71907-Ab-1/ GM-Tg-felg-T71907-Ab-2 Feline SMN-Exon7/SMN1 protein Feline
GM-Tg-cang-T71907-Ab-1/ GM-Tg-cang-T71907-Ab-2 Canine SMN-Exon7/SMN1 protein Canine
GM-Tg-bovg-T71907-Ab-1/ GM-Tg-bovg-T71907-Ab-2 Bovine SMN-Exon7/SMN1 protein Bovine
GM-Tg-equg-T71907-Ab-1/ GM-Tg-equg-T71907-Ab-2 Equine SMN-Exon7/SMN1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T71907-Ab-1/ GM-Tg-hg-T71907-Ab-2; GM-Tg-rg-T71907-Ab-1/ GM-Tg-rg-T71907-Ab-2;
GM-Tg-mg-T71907-Ab-1/ GM-Tg-mg-T71907-Ab-2; GM-Tg-cynog-T71907-Ab-1/ GM-Tg-cynog-T71907-Ab-2;
GM-Tg-felg-T71907-Ab-1/ GM-Tg-felg-T71907-Ab-2; GM-Tg-cang-T71907-Ab-1/ GM-Tg-cang-T71907-Ab-2;
GM-Tg-bovg-T71907-Ab-1/ GM-Tg-bovg-T71907-Ab-2; GM-Tg-equg-T71907-Ab-1/ GM-Tg-equg-T71907-Ab-2
Products Name SMN-Exon7/SMN1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMN-Exon7/SMN1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMN-Exon7/SMN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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