Recombinant multi-species LIMK1/LIMK-1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LIMK1/LIMK-1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
The Alternative Names of target: LIMK1, LIMK-1,LIM domain kinase 1,LIMK-1,LIMK,LIMK-1

Target products collectionGo to LIMK1/LIMK-1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T70840-Ab-1/ GM-Tg-hg-T70840-Ab-2 Human LIMK1/LIMK-1 protein Human
GM-Tg-rg-T70840-Ab-1/ GM-Tg-rg-T70840-Ab-2 Rat LIMK1/LIMK-1 protein Rat
GM-Tg-mg-T70840-Ab-1/ GM-Tg-mg-T70840-Ab-2 Mouse LIMK1/LIMK-1 protein Mouse
GM-Tg-cynog-T70840-Ab-1/ GM-Tg-cynog-T70840-Ab-2 Cynomolgus/Rhesus macaque LIMK1/LIMK-1 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T70840-Ab-1/ GM-Tg-felg-T70840-Ab-2 Feline LIMK1/LIMK-1 protein Feline
GM-Tg-cang-T70840-Ab-1/ GM-Tg-cang-T70840-Ab-2 Canine LIMK1/LIMK-1 protein Canine
GM-Tg-bovg-T70840-Ab-1/ GM-Tg-bovg-T70840-Ab-2 Bovine LIMK1/LIMK-1 protein Bovine
GM-Tg-equg-T70840-Ab-1/ GM-Tg-equg-T70840-Ab-2 Equine LIMK1/LIMK-1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T70840-Ab-1/ GM-Tg-hg-T70840-Ab-2; GM-Tg-rg-T70840-Ab-1/ GM-Tg-rg-T70840-Ab-2;
GM-Tg-mg-T70840-Ab-1/ GM-Tg-mg-T70840-Ab-2; GM-Tg-cynog-T70840-Ab-1/ GM-Tg-cynog-T70840-Ab-2;
GM-Tg-felg-T70840-Ab-1/ GM-Tg-felg-T70840-Ab-2; GM-Tg-cang-T70840-Ab-1/ GM-Tg-cang-T70840-Ab-2;
GM-Tg-bovg-T70840-Ab-1/ GM-Tg-bovg-T70840-Ab-2; GM-Tg-equg-T70840-Ab-1/ GM-Tg-equg-T70840-Ab-2
Products Name LIMK1/LIMK-1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LIMK1/LIMK-1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LIMK1/LIMK-1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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