Recombinant multi-species GPX1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GPX1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]
The Alternative Names of target: CGPx,Cellular glutathione peroxidase,GPX1,GPXD,GPx-1,GSHPX1,GSHPx,GSHPx-1,Glutathione peroxidase 1,Gpx,Gpx1,Phospholipid-hydroperoxide glutathione peroxidase GPX1

Target products collectionGo to GPX1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T70654-Ag-1/ GM-Tg-hg-T70654-Ag-2 Human GPX1 protein Human
GM-Tg-rg-T70654-Ag-1/ GM-Tg-rg-T70654-Ag-2 Rat GPX1 protein Rat
GM-Tg-mg-T70654-Ag-1/ GM-Tg-mg-T70654-Ag-2 Mouse GPX1 protein Mouse
GM-Tg-cynog-T70654-Ag-1/ GM-Tg-cynog-T70654-Ag-2 Cynomolgus/Rhesus macaque GPX1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T70654-Ag-1/ GM-Tg-felg-T70654-Ag-2 Feline GPX1 protein Feline
GM-Tg-cang-T70654-Ag-1/ GM-Tg-cang-T70654-Ag-2 Canine GPX1 protein Canine
GM-Tg-bovg-T70654-Ag-1/ GM-Tg-bovg-T70654-Ag-2 Bovine GPX1 protein Bovine
GM-Tg-equg-T70654-Ag-1/ GM-Tg-equg-T70654-Ag-2 Equine GPX1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T70654-Ag-1/ GM-Tg-hg-T70654-Ag-2; GM-Tg-rg-T70654-Ag-1/ GM-Tg-rg-T70654-Ag-2;
GM-Tg-mg-T70654-Ag-1/ GM-Tg-mg-T70654-Ag-2; GM-Tg-cynog-T70654-Ag-1/ GM-Tg-cynog-T70654-Ag-2;
GM-Tg-felg-T70654-Ag-1/ GM-Tg-felg-T70654-Ag-2; GM-Tg-cang-T70654-Ag-1/ GM-Tg-cang-T70654-Ag-2;
GM-Tg-bovg-T70654-Ag-1/ GM-Tg-bovg-T70654-Ag-2; GM-Tg-equg-T70654-Ag-1/ GM-Tg-equg-T70654-Ag-2
Products Name GPX1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GPX1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GPX1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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