Recombinant multi-species IDH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
The Alternative Names of target: Cytosolic NADP-isocitrate dehydrogenase,E030024J03Rik,HEL-216,HEL-S-26,IDCD,IDH,IDH1,IDP,IDPC,IDPc,Id-1,Idh-1,Idh1,Idpc,Isocitrate dehydrogenase [NADP] cytoplasmic,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase,PICD

Target products collectionGo to IDH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T69563-Ag-1/ GM-Tg-hg-T69563-Ag-2 Human IDH1 protein Human
GM-Tg-rg-T69563-Ag-1/ GM-Tg-rg-T69563-Ag-2 Rat IDH1 protein Rat
GM-Tg-mg-T69563-Ag-1/ GM-Tg-mg-T69563-Ag-2 Mouse IDH1 protein Mouse
GM-Tg-cynog-T69563-Ag-1/ GM-Tg-cynog-T69563-Ag-2 Cynomolgus/Rhesus macaque IDH1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T69563-Ag-1/ GM-Tg-felg-T69563-Ag-2 Feline IDH1 protein Feline
GM-Tg-cang-T69563-Ag-1/ GM-Tg-cang-T69563-Ag-2 Canine IDH1 protein Canine
GM-Tg-bovg-T69563-Ag-1/ GM-Tg-bovg-T69563-Ag-2 Bovine IDH1 protein Bovine
GM-Tg-equg-T69563-Ag-1/ GM-Tg-equg-T69563-Ag-2 Equine IDH1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T69563-Ag-1/ GM-Tg-hg-T69563-Ag-2; GM-Tg-rg-T69563-Ag-1/ GM-Tg-rg-T69563-Ag-2;
GM-Tg-mg-T69563-Ag-1/ GM-Tg-mg-T69563-Ag-2; GM-Tg-cynog-T69563-Ag-1/ GM-Tg-cynog-T69563-Ag-2;
GM-Tg-felg-T69563-Ag-1/ GM-Tg-felg-T69563-Ag-2; GM-Tg-cang-T69563-Ag-1/ GM-Tg-cang-T69563-Ag-2;
GM-Tg-bovg-T69563-Ag-1/ GM-Tg-bovg-T69563-Ag-2; GM-Tg-equg-T69563-Ag-1/ GM-Tg-equg-T69563-Ag-2
Products Name IDH1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IDH1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDH1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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