Recombinant multi-species NR1I3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1I3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
The Alternative Names of target: CAR,CAR-beta,CAR1,Care2,Constitutive activator of retinoid response (Constitutive active response),Constitutive androstane receptor (CAR),ESTM32,MB67,NR1I3,Nr1i3,Nuclear receptor subfamily 1 group I member 3,Orphan nuclear receptor MB67

Target products collectionGo to NR1I3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T69506-Ag-1/ GM-Tg-hg-T69506-Ag-2 Human NR1I3 protein Human
GM-Tg-rg-T69506-Ag-1/ GM-Tg-rg-T69506-Ag-2 Rat NR1I3 protein Rat
GM-Tg-mg-T69506-Ag-1/ GM-Tg-mg-T69506-Ag-2 Mouse NR1I3 protein Mouse
GM-Tg-cynog-T69506-Ag-1/ GM-Tg-cynog-T69506-Ag-2 Cynomolgus/Rhesus macaque NR1I3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T69506-Ag-1/ GM-Tg-felg-T69506-Ag-2 Feline NR1I3 protein Feline
GM-Tg-cang-T69506-Ag-1/ GM-Tg-cang-T69506-Ag-2 Canine NR1I3 protein Canine
GM-Tg-bovg-T69506-Ag-1/ GM-Tg-bovg-T69506-Ag-2 Bovine NR1I3 protein Bovine
GM-Tg-equg-T69506-Ag-1/ GM-Tg-equg-T69506-Ag-2 Equine NR1I3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T69506-Ag-1/ GM-Tg-hg-T69506-Ag-2; GM-Tg-rg-T69506-Ag-1/ GM-Tg-rg-T69506-Ag-2;
GM-Tg-mg-T69506-Ag-1/ GM-Tg-mg-T69506-Ag-2; GM-Tg-cynog-T69506-Ag-1/ GM-Tg-cynog-T69506-Ag-2;
GM-Tg-felg-T69506-Ag-1/ GM-Tg-felg-T69506-Ag-2; GM-Tg-cang-T69506-Ag-1/ GM-Tg-cang-T69506-Ag-2;
GM-Tg-bovg-T69506-Ag-1/ GM-Tg-bovg-T69506-Ag-2; GM-Tg-equg-T69506-Ag-1/ GM-Tg-equg-T69506-Ag-2
Products Name NR1I3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NR1I3
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NR1I3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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