Recombinant multi-species Factor XIIIa/F13A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Factor XIIIa/F13A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 1200014I03Rik,Coagulation factor XIII A chain,Coagulation factor XIIIa,F13A,F13A1,F13a,F13a1,Factor XIIIa,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain

Target products collectionGo to Factor XIIIa/F13A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T66925-Ag-1/ GM-Tg-hg-T66925-Ag-2 Human Factor XIIIa/F13A1 protein Human
GM-Tg-rg-T66925-Ag-1/ GM-Tg-rg-T66925-Ag-2 Rat Factor XIIIa/F13A1 protein Rat
GM-Tg-mg-T66925-Ag-1/ GM-Tg-mg-T66925-Ag-2 Mouse Factor XIIIa/F13A1 protein Mouse
GM-Tg-cynog-T66925-Ag-1/ GM-Tg-cynog-T66925-Ag-2 Cynomolgus/Rhesus macaque Factor XIIIa/F13A1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T66925-Ag-1/ GM-Tg-felg-T66925-Ag-2 Feline Factor XIIIa/F13A1 protein Feline
GM-Tg-cang-T66925-Ag-1/ GM-Tg-cang-T66925-Ag-2 Canine Factor XIIIa/F13A1 protein Canine
GM-Tg-bovg-T66925-Ag-1/ GM-Tg-bovg-T66925-Ag-2 Bovine Factor XIIIa/F13A1 protein Bovine
GM-Tg-equg-T66925-Ag-1/ GM-Tg-equg-T66925-Ag-2 Equine Factor XIIIa/F13A1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T66925-Ag-1/ GM-Tg-hg-T66925-Ag-2; GM-Tg-rg-T66925-Ag-1/ GM-Tg-rg-T66925-Ag-2;
GM-Tg-mg-T66925-Ag-1/ GM-Tg-mg-T66925-Ag-2; GM-Tg-cynog-T66925-Ag-1/ GM-Tg-cynog-T66925-Ag-2;
GM-Tg-felg-T66925-Ag-1/ GM-Tg-felg-T66925-Ag-2; GM-Tg-cang-T66925-Ag-1/ GM-Tg-cang-T66925-Ag-2;
GM-Tg-bovg-T66925-Ag-1/ GM-Tg-bovg-T66925-Ag-2; GM-Tg-equg-T66925-Ag-1/ GM-Tg-equg-T66925-Ag-2
Products Name Factor XIIIa/F13A1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Factor XIIIa/F13A1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Factor XIIIa/F13A1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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