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Recombinant multi-species AGT/Angiotensinogen protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AGT/Angiotensinogen protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]
The Alternative Names of target: AGT, Angiotensinogen,Angiotensinogen,Serpin A8,ANHU,hFLT1,SERPINA8
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(antibodies,
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64485-Ab-1/ GM-Tg-hg-T64485-Ab-2 | Human AGT/Angiotensinogen protein | Human |
| GM-Tg-rg-T64485-Ab-1/ GM-Tg-rg-T64485-Ab-2 | Rat AGT/Angiotensinogen protein | Rat |
| GM-Tg-mg-T64485-Ab-1/ GM-Tg-mg-T64485-Ab-2 | Mouse AGT/Angiotensinogen protein | Mouse |
| GM-Tg-cynog-T64485-Ab-1/ GM-Tg-cynog-T64485-Ab-2 | Cynomolgus/Rhesus macaque AGT/Angiotensinogen monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64485-Ab-1/ GM-Tg-felg-T64485-Ab-2 | Feline AGT/Angiotensinogen protein | Feline |
| GM-Tg-cang-T64485-Ab-1/ GM-Tg-cang-T64485-Ab-2 | Canine AGT/Angiotensinogen protein | Canine |
| GM-Tg-bovg-T64485-Ab-1/ GM-Tg-bovg-T64485-Ab-2 | Bovine AGT/Angiotensinogen protein | Bovine |
| GM-Tg-equg-T64485-Ab-1/ GM-Tg-equg-T64485-Ab-2 | Equine AGT/Angiotensinogen protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T64485-Ab-1/ GM-Tg-hg-T64485-Ab-2;
GM-Tg-rg-T64485-Ab-1/ GM-Tg-rg-T64485-Ab-2;
GM-Tg-mg-T64485-Ab-1/ GM-Tg-mg-T64485-Ab-2; GM-Tg-cynog-T64485-Ab-1/ GM-Tg-cynog-T64485-Ab-2; GM-Tg-felg-T64485-Ab-1/ GM-Tg-felg-T64485-Ab-2; GM-Tg-cang-T64485-Ab-1/ GM-Tg-cang-T64485-Ab-2; GM-Tg-bovg-T64485-Ab-1/ GM-Tg-bovg-T64485-Ab-2; GM-Tg-equg-T64485-Ab-1/ GM-Tg-equg-T64485-Ab-2 |
| Products Name | AGT/Angiotensinogen protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | AGT/Angiotensinogen |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine AGT/Angiotensinogen protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.