Recombinant multi-species CRH/CRF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CRH/CRF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]
The Alternative Names of target: CRF,CRH,CRH1,Corticoliberin,Corticotropin-releasing factor (CRF),Corticotropin-releasing hormone,Crh,Gm1347

Target products collectionGo to CRH/CRF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T64137-Ag-1/ GM-Tg-hg-T64137-Ag-2 Human CRH/CRF protein Human
GM-Tg-rg-T64137-Ag-1/ GM-Tg-rg-T64137-Ag-2 Rat CRH/CRF protein Rat
GM-Tg-mg-T64137-Ag-1/ GM-Tg-mg-T64137-Ag-2 Mouse CRH/CRF protein Mouse
GM-Tg-cynog-T64137-Ag-1/ GM-Tg-cynog-T64137-Ag-2 Cynomolgus/Rhesus macaque CRH/CRF protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T64137-Ag-1/ GM-Tg-felg-T64137-Ag-2 Feline CRH/CRF protein Feline
GM-Tg-cang-T64137-Ag-1/ GM-Tg-cang-T64137-Ag-2 Canine CRH/CRF protein Canine
GM-Tg-bovg-T64137-Ag-1/ GM-Tg-bovg-T64137-Ag-2 Bovine CRH/CRF protein Bovine
GM-Tg-equg-T64137-Ag-1/ GM-Tg-equg-T64137-Ag-2 Equine CRH/CRF protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T64137-Ag-1/ GM-Tg-hg-T64137-Ag-2; GM-Tg-rg-T64137-Ag-1/ GM-Tg-rg-T64137-Ag-2;
GM-Tg-mg-T64137-Ag-1/ GM-Tg-mg-T64137-Ag-2; GM-Tg-cynog-T64137-Ag-1/ GM-Tg-cynog-T64137-Ag-2;
GM-Tg-felg-T64137-Ag-1/ GM-Tg-felg-T64137-Ag-2; GM-Tg-cang-T64137-Ag-1/ GM-Tg-cang-T64137-Ag-2;
GM-Tg-bovg-T64137-Ag-1/ GM-Tg-bovg-T64137-Ag-2; GM-Tg-equg-T64137-Ag-1/ GM-Tg-equg-T64137-Ag-2
Products Name CRH/CRF protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CRH/CRF
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CRH/CRF protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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