Recombinant multi-species Importin Beta/KPNB1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Importin Beta/KPNB1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
The Alternative Names of target: IMB1,IPO1,IPOB,Impnb,Importin Beta,Importin subunit beta-1,Importin-90,KPNB1,Karyopherin subunit beta-1,Kpnb1,NTF97,Nuclear factor p97,Pore targeting complex 97 kDa subunit (PTAC97)

Target products collectionGo to Importin Beta/KPNB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T64022-Ag-1/ GM-Tg-hg-T64022-Ag-2 Human Importin Beta/KPNB1 protein Human
GM-Tg-rg-T64022-Ag-1/ GM-Tg-rg-T64022-Ag-2 Rat Importin Beta/KPNB1 protein Rat
GM-Tg-mg-T64022-Ag-1/ GM-Tg-mg-T64022-Ag-2 Mouse Importin Beta/KPNB1 protein Mouse
GM-Tg-cynog-T64022-Ag-1/ GM-Tg-cynog-T64022-Ag-2 Cynomolgus/Rhesus macaque Importin Beta/KPNB1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T64022-Ag-1/ GM-Tg-felg-T64022-Ag-2 Feline Importin Beta/KPNB1 protein Feline
GM-Tg-cang-T64022-Ag-1/ GM-Tg-cang-T64022-Ag-2 Canine Importin Beta/KPNB1 protein Canine
GM-Tg-bovg-T64022-Ag-1/ GM-Tg-bovg-T64022-Ag-2 Bovine Importin Beta/KPNB1 protein Bovine
GM-Tg-equg-T64022-Ag-1/ GM-Tg-equg-T64022-Ag-2 Equine Importin Beta/KPNB1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T64022-Ag-1/ GM-Tg-hg-T64022-Ag-2; GM-Tg-rg-T64022-Ag-1/ GM-Tg-rg-T64022-Ag-2;
GM-Tg-mg-T64022-Ag-1/ GM-Tg-mg-T64022-Ag-2; GM-Tg-cynog-T64022-Ag-1/ GM-Tg-cynog-T64022-Ag-2;
GM-Tg-felg-T64022-Ag-1/ GM-Tg-felg-T64022-Ag-2; GM-Tg-cang-T64022-Ag-1/ GM-Tg-cang-T64022-Ag-2;
GM-Tg-bovg-T64022-Ag-1/ GM-Tg-bovg-T64022-Ag-2; GM-Tg-equg-T64022-Ag-1/ GM-Tg-equg-T64022-Ag-2
Products Name Importin Beta/KPNB1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Importin Beta/KPNB1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Importin Beta/KPNB1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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