Recombinant multi-species POMC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine POMC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
The Alternative Names of target: ACTH,BE,Beta-LPH,CLIP,Clip,Corticotropin-lipotropin,Gamma-LPH,LPH,MSH,NPP,Npp,OBAIRH,POC,POMC,Pomc,Pomc-1,Pomc1,Pomc2,Pro-opiomelanocortin,alpha-MSH,alphaMSH,beta-MSH,gamma-MSH

Target products collectionGo to POMC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T62912-Ag-1/ GM-Tg-hg-T62912-Ag-2 Human POMC protein Human
GM-Tg-rg-T62912-Ag-1/ GM-Tg-rg-T62912-Ag-2 Rat POMC protein Rat
GM-Tg-mg-T62912-Ag-1/ GM-Tg-mg-T62912-Ag-2 Mouse POMC protein Mouse
GM-Tg-cynog-T62912-Ag-1/ GM-Tg-cynog-T62912-Ag-2 Cynomolgus/Rhesus macaque POMC protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T62912-Ag-1/ GM-Tg-felg-T62912-Ag-2 Feline POMC protein Feline
GM-Tg-cang-T62912-Ag-1/ GM-Tg-cang-T62912-Ag-2 Canine POMC protein Canine
GM-Tg-bovg-T62912-Ag-1/ GM-Tg-bovg-T62912-Ag-2 Bovine POMC protein Bovine
GM-Tg-equg-T62912-Ag-1/ GM-Tg-equg-T62912-Ag-2 Equine POMC protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T62912-Ag-1/ GM-Tg-hg-T62912-Ag-2; GM-Tg-rg-T62912-Ag-1/ GM-Tg-rg-T62912-Ag-2;
GM-Tg-mg-T62912-Ag-1/ GM-Tg-mg-T62912-Ag-2; GM-Tg-cynog-T62912-Ag-1/ GM-Tg-cynog-T62912-Ag-2;
GM-Tg-felg-T62912-Ag-1/ GM-Tg-felg-T62912-Ag-2; GM-Tg-cang-T62912-Ag-1/ GM-Tg-cang-T62912-Ag-2;
GM-Tg-bovg-T62912-Ag-1/ GM-Tg-bovg-T62912-Ag-2; GM-Tg-equg-T62912-Ag-1/ GM-Tg-equg-T62912-Ag-2
Products Name POMC protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name POMC
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine POMC protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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