Recombinant multi-species JAK1/JAK-1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JAK1/JAK-1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]
The Alternative Names of target: AIIDE,BAP004,C130039L05Rik,JAK-1,JAK1,JAK1A,JAK1B,JTK3,Jak1,Janus kinase 1 (JAK-1),Tyrosine-protein kinase JAK1

Target products collectionGo to JAK1/JAK-1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T62460-Ag-1/ GM-Tg-hg-T62460-Ag-2 Human JAK1/JAK-1 protein Human
GM-Tg-rg-T62460-Ag-1/ GM-Tg-rg-T62460-Ag-2 Rat JAK1/JAK-1 protein Rat
GM-Tg-mg-T62460-Ag-1/ GM-Tg-mg-T62460-Ag-2 Mouse JAK1/JAK-1 protein Mouse
GM-Tg-cynog-T62460-Ag-1/ GM-Tg-cynog-T62460-Ag-2 Cynomolgus/Rhesus macaque JAK1/JAK-1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T62460-Ag-1/ GM-Tg-felg-T62460-Ag-2 Feline JAK1/JAK-1 protein Feline
GM-Tg-cang-T62460-Ag-1/ GM-Tg-cang-T62460-Ag-2 Canine JAK1/JAK-1 protein Canine
GM-Tg-bovg-T62460-Ag-1/ GM-Tg-bovg-T62460-Ag-2 Bovine JAK1/JAK-1 protein Bovine
GM-Tg-equg-T62460-Ag-1/ GM-Tg-equg-T62460-Ag-2 Equine JAK1/JAK-1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T62460-Ag-1/ GM-Tg-hg-T62460-Ag-2; GM-Tg-rg-T62460-Ag-1/ GM-Tg-rg-T62460-Ag-2;
GM-Tg-mg-T62460-Ag-1/ GM-Tg-mg-T62460-Ag-2; GM-Tg-cynog-T62460-Ag-1/ GM-Tg-cynog-T62460-Ag-2;
GM-Tg-felg-T62460-Ag-1/ GM-Tg-felg-T62460-Ag-2; GM-Tg-cang-T62460-Ag-1/ GM-Tg-cang-T62460-Ag-2;
GM-Tg-bovg-T62460-Ag-1/ GM-Tg-bovg-T62460-Ag-2; GM-Tg-equg-T62460-Ag-1/ GM-Tg-equg-T62460-Ag-2
Products Name JAK1/JAK-1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name JAK1/JAK-1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine JAK1/JAK-1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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