Recombinant multi-species ARMET/MANF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ARMET/MANF protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
The Alternative Names of target: ARMET, MANF,Mesencephalic astrocyte-derived neurotrophic factor,Arginine-rich protein, Protein ARMET,ARP,DDDS,ARMET

Target products collectionGo to ARMET/MANF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T62415-Ab-1/ GM-Tg-hg-T62415-Ab-2 Human ARMET/MANF protein Human
GM-Tg-rg-T62415-Ab-1/ GM-Tg-rg-T62415-Ab-2 Rat ARMET/MANF protein Rat
GM-Tg-mg-T62415-Ab-1/ GM-Tg-mg-T62415-Ab-2 Mouse ARMET/MANF protein Mouse
GM-Tg-cynog-T62415-Ab-1/ GM-Tg-cynog-T62415-Ab-2 Cynomolgus/Rhesus macaque ARMET/MANF monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T62415-Ab-1/ GM-Tg-felg-T62415-Ab-2 Feline ARMET/MANF protein Feline
GM-Tg-cang-T62415-Ab-1/ GM-Tg-cang-T62415-Ab-2 Canine ARMET/MANF protein Canine
GM-Tg-bovg-T62415-Ab-1/ GM-Tg-bovg-T62415-Ab-2 Bovine ARMET/MANF protein Bovine
GM-Tg-equg-T62415-Ab-1/ GM-Tg-equg-T62415-Ab-2 Equine ARMET/MANF protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T62415-Ab-1/ GM-Tg-hg-T62415-Ab-2; GM-Tg-rg-T62415-Ab-1/ GM-Tg-rg-T62415-Ab-2;
GM-Tg-mg-T62415-Ab-1/ GM-Tg-mg-T62415-Ab-2; GM-Tg-cynog-T62415-Ab-1/ GM-Tg-cynog-T62415-Ab-2;
GM-Tg-felg-T62415-Ab-1/ GM-Tg-felg-T62415-Ab-2; GM-Tg-cang-T62415-Ab-1/ GM-Tg-cang-T62415-Ab-2;
GM-Tg-bovg-T62415-Ab-1/ GM-Tg-bovg-T62415-Ab-2; GM-Tg-equg-T62415-Ab-1/ GM-Tg-equg-T62415-Ab-2
Products Name ARMET/MANF protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ARMET/MANF
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ARMET/MANF protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.