Recombinant multi-species Cathepsin B/CTSB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cathepsin B/CTSB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]
The Alternative Names of target: APP secretase (APPS),APPS,CATB,CB,CPSB,CTSB,Cathepsin B,Cathepsin B1,Ctsb,KWE,RECEUP

Target products collectionGo to Cathepsin B/CTSB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T61746-Ag-1/ GM-Tg-hg-T61746-Ag-2 Human Cathepsin B/CTSB protein Human
GM-Tg-rg-T61746-Ag-1/ GM-Tg-rg-T61746-Ag-2 Rat Cathepsin B/CTSB protein Rat
GM-Tg-mg-T61746-Ag-1/ GM-Tg-mg-T61746-Ag-2 Mouse Cathepsin B/CTSB protein Mouse
GM-Tg-cynog-T61746-Ag-1/ GM-Tg-cynog-T61746-Ag-2 Cynomolgus/Rhesus macaque Cathepsin B/CTSB protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T61746-Ag-1/ GM-Tg-felg-T61746-Ag-2 Feline Cathepsin B/CTSB protein Feline
GM-Tg-cang-T61746-Ag-1/ GM-Tg-cang-T61746-Ag-2 Canine Cathepsin B/CTSB protein Canine
GM-Tg-bovg-T61746-Ag-1/ GM-Tg-bovg-T61746-Ag-2 Bovine Cathepsin B/CTSB protein Bovine
GM-Tg-equg-T61746-Ag-1/ GM-Tg-equg-T61746-Ag-2 Equine Cathepsin B/CTSB protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T61746-Ag-1/ GM-Tg-hg-T61746-Ag-2; GM-Tg-rg-T61746-Ag-1/ GM-Tg-rg-T61746-Ag-2;
GM-Tg-mg-T61746-Ag-1/ GM-Tg-mg-T61746-Ag-2; GM-Tg-cynog-T61746-Ag-1/ GM-Tg-cynog-T61746-Ag-2;
GM-Tg-felg-T61746-Ag-1/ GM-Tg-felg-T61746-Ag-2; GM-Tg-cang-T61746-Ag-1/ GM-Tg-cang-T61746-Ag-2;
GM-Tg-bovg-T61746-Ag-1/ GM-Tg-bovg-T61746-Ag-2; GM-Tg-equg-T61746-Ag-1/ GM-Tg-equg-T61746-Ag-2
Products Name Cathepsin B/CTSB protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Cathepsin B/CTSB
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Cathepsin B/CTSB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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