Recombinant multi-species C5/CO5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine C5/CO5 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
The Alternative Names of target: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4,C5,C5D,C5a,C5b,CO5,CPAMD4,Complement C5,ECLZB,Hc,He,Hfib2,RGD1561905

Target products collectionGo to C5/CO5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T60708-Ag-1/ GM-Tg-hg-T60708-Ag-2 Human C5/CO5 protein Human
GM-Tg-rg-T60708-Ag-1/ GM-Tg-rg-T60708-Ag-2 Rat C5/CO5 protein Rat
GM-Tg-mg-T60708-Ag-1/ GM-Tg-mg-T60708-Ag-2 Mouse C5/CO5 protein Mouse
GM-Tg-cynog-T60708-Ag-1/ GM-Tg-cynog-T60708-Ag-2 Cynomolgus/Rhesus macaque C5/CO5 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T60708-Ag-1/ GM-Tg-felg-T60708-Ag-2 Feline C5/CO5 protein Feline
GM-Tg-cang-T60708-Ag-1/ GM-Tg-cang-T60708-Ag-2 Canine C5/CO5 protein Canine
GM-Tg-bovg-T60708-Ag-1/ GM-Tg-bovg-T60708-Ag-2 Bovine C5/CO5 protein Bovine
GM-Tg-equg-T60708-Ag-1/ GM-Tg-equg-T60708-Ag-2 Equine C5/CO5 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T60708-Ag-1/ GM-Tg-hg-T60708-Ag-2; GM-Tg-rg-T60708-Ag-1/ GM-Tg-rg-T60708-Ag-2;
GM-Tg-mg-T60708-Ag-1/ GM-Tg-mg-T60708-Ag-2; GM-Tg-cynog-T60708-Ag-1/ GM-Tg-cynog-T60708-Ag-2;
GM-Tg-felg-T60708-Ag-1/ GM-Tg-felg-T60708-Ag-2; GM-Tg-cang-T60708-Ag-1/ GM-Tg-cang-T60708-Ag-2;
GM-Tg-bovg-T60708-Ag-1/ GM-Tg-bovg-T60708-Ag-2; GM-Tg-equg-T60708-Ag-1/ GM-Tg-equg-T60708-Ag-2
Products Name C5/CO5 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name C5/CO5
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine C5/CO5 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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