Recombinant multi-species MECP2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MECP2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
The Alternative Names of target: 1500041B07Rik,AUTSX3,D630021H01Rik,MECP2,MECP2_e1,MRX16,MRX79,MRXS13,MRXSL,Mbd5,MeCp-2 protein,MeCp2,Mecp2,Methyl-CpG-binding protein 2,PPMX,RS,RTS,RTT,WBP10

Target products collectionGo to MECP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T59686-Ag-1/ GM-Tg-hg-T59686-Ag-2 Human MECP2 protein Human
GM-Tg-rg-T59686-Ag-1/ GM-Tg-rg-T59686-Ag-2 Rat MECP2 protein Rat
GM-Tg-mg-T59686-Ag-1/ GM-Tg-mg-T59686-Ag-2 Mouse MECP2 protein Mouse
GM-Tg-cynog-T59686-Ag-1/ GM-Tg-cynog-T59686-Ag-2 Cynomolgus/Rhesus macaque MECP2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T59686-Ag-1/ GM-Tg-felg-T59686-Ag-2 Feline MECP2 protein Feline
GM-Tg-cang-T59686-Ag-1/ GM-Tg-cang-T59686-Ag-2 Canine MECP2 protein Canine
GM-Tg-bovg-T59686-Ag-1/ GM-Tg-bovg-T59686-Ag-2 Bovine MECP2 protein Bovine
GM-Tg-equg-T59686-Ag-1/ GM-Tg-equg-T59686-Ag-2 Equine MECP2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T59686-Ag-1/ GM-Tg-hg-T59686-Ag-2; GM-Tg-rg-T59686-Ag-1/ GM-Tg-rg-T59686-Ag-2;
GM-Tg-mg-T59686-Ag-1/ GM-Tg-mg-T59686-Ag-2; GM-Tg-cynog-T59686-Ag-1/ GM-Tg-cynog-T59686-Ag-2;
GM-Tg-felg-T59686-Ag-1/ GM-Tg-felg-T59686-Ag-2; GM-Tg-cang-T59686-Ag-1/ GM-Tg-cang-T59686-Ag-2;
GM-Tg-bovg-T59686-Ag-1/ GM-Tg-bovg-T59686-Ag-2; GM-Tg-equg-T59686-Ag-1/ GM-Tg-equg-T59686-Ag-2
Products Name MECP2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MECP2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MECP2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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