Recombinant multi-species KRAS G12C protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KRAS G12C protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 'C-K-RAS,C-K-RAS,CFC2,GTPase KRas,K-RAS,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,K-Ras,K-Ras 2,K-ras,KI-RAS,KRAS,KRAS G12C,KRAS1,KRAS2,Ki-Ras,Ki-ras,Kras,Kras-2,Kras2,NS,NS3,OES,RALD,RASK2,c-K-ras,c-Ki-ras,c-Ki-ras2,p21,p21B,p21ras,ras

Target products collectionGo to KRAS G12C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T59480-Ag-1/ GM-Tg-hg-T59480-Ag-2 Human KRAS G12C protein Human
GM-Tg-rg-T59480-Ag-1/ GM-Tg-rg-T59480-Ag-2 Rat KRAS G12C protein Rat
GM-Tg-mg-T59480-Ag-1/ GM-Tg-mg-T59480-Ag-2 Mouse KRAS G12C protein Mouse
GM-Tg-cynog-T59480-Ag-1/ GM-Tg-cynog-T59480-Ag-2 Cynomolgus/Rhesus macaque KRAS G12C protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T59480-Ag-1/ GM-Tg-felg-T59480-Ag-2 Feline KRAS G12C protein Feline
GM-Tg-cang-T59480-Ag-1/ GM-Tg-cang-T59480-Ag-2 Canine KRAS G12C protein Canine
GM-Tg-bovg-T59480-Ag-1/ GM-Tg-bovg-T59480-Ag-2 Bovine KRAS G12C protein Bovine
GM-Tg-equg-T59480-Ag-1/ GM-Tg-equg-T59480-Ag-2 Equine KRAS G12C protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T59480-Ag-1/ GM-Tg-hg-T59480-Ag-2; GM-Tg-rg-T59480-Ag-1/ GM-Tg-rg-T59480-Ag-2;
GM-Tg-mg-T59480-Ag-1/ GM-Tg-mg-T59480-Ag-2; GM-Tg-cynog-T59480-Ag-1/ GM-Tg-cynog-T59480-Ag-2;
GM-Tg-felg-T59480-Ag-1/ GM-Tg-felg-T59480-Ag-2; GM-Tg-cang-T59480-Ag-1/ GM-Tg-cang-T59480-Ag-2;
GM-Tg-bovg-T59480-Ag-1/ GM-Tg-bovg-T59480-Ag-2; GM-Tg-equg-T59480-Ag-1/ GM-Tg-equg-T59480-Ag-2
Products Name KRAS G12C protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name KRAS G12C
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KRAS G12C protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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