Recombinant multi-species ABAT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABAT protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ABAT,4-aminobutyrate aminotransferase, mitochondrial,(S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase (GABA-AT), Gamma-amino-N-butyrate transaminase (GABA transaminase, GABA-T), L-AIBAT,GABAT,NPD009,GABA-AT

Target products collectionGo to ABAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T59045-Ab-1/ GM-Tg-hg-T59045-Ab-2 Human ABAT protein Human
GM-Tg-rg-T59045-Ab-1/ GM-Tg-rg-T59045-Ab-2 Rat ABAT protein Rat
GM-Tg-mg-T59045-Ab-1/ GM-Tg-mg-T59045-Ab-2 Mouse ABAT protein Mouse
GM-Tg-cynog-T59045-Ab-1/ GM-Tg-cynog-T59045-Ab-2 Cynomolgus/Rhesus macaque ABAT monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T59045-Ab-1/ GM-Tg-felg-T59045-Ab-2 Feline ABAT protein Feline
GM-Tg-cang-T59045-Ab-1/ GM-Tg-cang-T59045-Ab-2 Canine ABAT protein Canine
GM-Tg-bovg-T59045-Ab-1/ GM-Tg-bovg-T59045-Ab-2 Bovine ABAT protein Bovine
GM-Tg-equg-T59045-Ab-1/ GM-Tg-equg-T59045-Ab-2 Equine ABAT protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T59045-Ab-1/ GM-Tg-hg-T59045-Ab-2; GM-Tg-rg-T59045-Ab-1/ GM-Tg-rg-T59045-Ab-2;
GM-Tg-mg-T59045-Ab-1/ GM-Tg-mg-T59045-Ab-2; GM-Tg-cynog-T59045-Ab-1/ GM-Tg-cynog-T59045-Ab-2;
GM-Tg-felg-T59045-Ab-1/ GM-Tg-felg-T59045-Ab-2; GM-Tg-cang-T59045-Ab-1/ GM-Tg-cang-T59045-Ab-2;
GM-Tg-bovg-T59045-Ab-1/ GM-Tg-bovg-T59045-Ab-2; GM-Tg-equg-T59045-Ab-1/ GM-Tg-equg-T59045-Ab-2
Products Name ABAT protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ABAT
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABAT protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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