Recombinant multi-species E2F1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine E2F1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.  This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
The Alternative Names of target: E2F-1,E2F1,E2f1,PBR3,RBAP1,RBBP3,RBP3,Retinoblastoma-associated protein 1 (RBAP-1),Retinoblastoma-binding protein 3 (RBBP-3),Tg(Wnt1-cre)2Sor,Transcription factor E2F1,mKIAA4009,pRB-binding protein E2F-1

Target products collectionGo to E2F1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T57059-Ag-1/ GM-Tg-hg-T57059-Ag-2 Human E2F1 protein Human
GM-Tg-rg-T57059-Ag-1/ GM-Tg-rg-T57059-Ag-2 Rat E2F1 protein Rat
GM-Tg-mg-T57059-Ag-1/ GM-Tg-mg-T57059-Ag-2 Mouse E2F1 protein Mouse
GM-Tg-cynog-T57059-Ag-1/ GM-Tg-cynog-T57059-Ag-2 Cynomolgus/Rhesus macaque E2F1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T57059-Ag-1/ GM-Tg-felg-T57059-Ag-2 Feline E2F1 protein Feline
GM-Tg-cang-T57059-Ag-1/ GM-Tg-cang-T57059-Ag-2 Canine E2F1 protein Canine
GM-Tg-bovg-T57059-Ag-1/ GM-Tg-bovg-T57059-Ag-2 Bovine E2F1 protein Bovine
GM-Tg-equg-T57059-Ag-1/ GM-Tg-equg-T57059-Ag-2 Equine E2F1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T57059-Ag-1/ GM-Tg-hg-T57059-Ag-2; GM-Tg-rg-T57059-Ag-1/ GM-Tg-rg-T57059-Ag-2;
GM-Tg-mg-T57059-Ag-1/ GM-Tg-mg-T57059-Ag-2; GM-Tg-cynog-T57059-Ag-1/ GM-Tg-cynog-T57059-Ag-2;
GM-Tg-felg-T57059-Ag-1/ GM-Tg-felg-T57059-Ag-2; GM-Tg-cang-T57059-Ag-1/ GM-Tg-cang-T57059-Ag-2;
GM-Tg-bovg-T57059-Ag-1/ GM-Tg-bovg-T57059-Ag-2; GM-Tg-equg-T57059-Ag-1/ GM-Tg-equg-T57059-Ag-2
Products Name E2F1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name E2F1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine E2F1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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