Recombinant multi-species Angiogenin/ANG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Angiogenin/ANG protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]
The Alternative Names of target: Angiogenin, ANG,Angiogenin,Ribonuclease 5 (RNase 5),ALS9,RAA1,HEL168,RNASE4,RNASE5

Target products collectionGo to Angiogenin/ANG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T54229-Ab-1/ GM-Tg-hg-T54229-Ab-2 Human Angiogenin/ANG protein Human
GM-Tg-rg-T54229-Ab-1/ GM-Tg-rg-T54229-Ab-2 Rat Angiogenin/ANG protein Rat
GM-Tg-mg-T54229-Ab-1/ GM-Tg-mg-T54229-Ab-2 Mouse Angiogenin/ANG protein Mouse
GM-Tg-cynog-T54229-Ab-1/ GM-Tg-cynog-T54229-Ab-2 Cynomolgus/Rhesus macaque Angiogenin/ANG monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T54229-Ab-1/ GM-Tg-felg-T54229-Ab-2 Feline Angiogenin/ANG protein Feline
GM-Tg-cang-T54229-Ab-1/ GM-Tg-cang-T54229-Ab-2 Canine Angiogenin/ANG protein Canine
GM-Tg-bovg-T54229-Ab-1/ GM-Tg-bovg-T54229-Ab-2 Bovine Angiogenin/ANG protein Bovine
GM-Tg-equg-T54229-Ab-1/ GM-Tg-equg-T54229-Ab-2 Equine Angiogenin/ANG protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T54229-Ab-1/ GM-Tg-hg-T54229-Ab-2; GM-Tg-rg-T54229-Ab-1/ GM-Tg-rg-T54229-Ab-2;
GM-Tg-mg-T54229-Ab-1/ GM-Tg-mg-T54229-Ab-2; GM-Tg-cynog-T54229-Ab-1/ GM-Tg-cynog-T54229-Ab-2;
GM-Tg-felg-T54229-Ab-1/ GM-Tg-felg-T54229-Ab-2; GM-Tg-cang-T54229-Ab-1/ GM-Tg-cang-T54229-Ab-2;
GM-Tg-bovg-T54229-Ab-1/ GM-Tg-bovg-T54229-Ab-2; GM-Tg-equg-T54229-Ab-1/ GM-Tg-equg-T54229-Ab-2
Products Name Angiogenin/ANG protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Angiogenin/ANG
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Angiogenin/ANG protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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