Recombinant multi-species PPM1D protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PPM1D protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
The Alternative Names of target: IDDGIP,JDVS,PP2C-DELTA,PPM1D,Ppm1d,Protein phosphatase 1D,Protein phosphatase 2C isoform delta (PP2C-delta),Protein phosphatase magnesium-dependent 1 delta,WIP1,Wip1,p53-induced protein phosphatase 1

Target products collectionGo to PPM1D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T50914-Ag-1/ GM-Tg-hg-T50914-Ag-2 Human PPM1D protein Human
GM-Tg-rg-T50914-Ag-1/ GM-Tg-rg-T50914-Ag-2 Rat PPM1D protein Rat
GM-Tg-mg-T50914-Ag-1/ GM-Tg-mg-T50914-Ag-2 Mouse PPM1D protein Mouse
GM-Tg-cynog-T50914-Ag-1/ GM-Tg-cynog-T50914-Ag-2 Cynomolgus/Rhesus macaque PPM1D protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T50914-Ag-1/ GM-Tg-felg-T50914-Ag-2 Feline PPM1D protein Feline
GM-Tg-cang-T50914-Ag-1/ GM-Tg-cang-T50914-Ag-2 Canine PPM1D protein Canine
GM-Tg-bovg-T50914-Ag-1/ GM-Tg-bovg-T50914-Ag-2 Bovine PPM1D protein Bovine
GM-Tg-equg-T50914-Ag-1/ GM-Tg-equg-T50914-Ag-2 Equine PPM1D protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T50914-Ag-1/ GM-Tg-hg-T50914-Ag-2; GM-Tg-rg-T50914-Ag-1/ GM-Tg-rg-T50914-Ag-2;
GM-Tg-mg-T50914-Ag-1/ GM-Tg-mg-T50914-Ag-2; GM-Tg-cynog-T50914-Ag-1/ GM-Tg-cynog-T50914-Ag-2;
GM-Tg-felg-T50914-Ag-1/ GM-Tg-felg-T50914-Ag-2; GM-Tg-cang-T50914-Ag-1/ GM-Tg-cang-T50914-Ag-2;
GM-Tg-bovg-T50914-Ag-1/ GM-Tg-bovg-T50914-Ag-2; GM-Tg-equg-T50914-Ag-1/ GM-Tg-equg-T50914-Ag-2
Products Name PPM1D protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PPM1D
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PPM1D protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.