Recombinant multi-species CHMP4B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHMP4B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
The Alternative Names of target: 2010012F05Rik,C20orf178,CHMP4A,CHMP4B,CTPP3,CTRCT31,Charged multivesicular body protein 4b,Chmp4b,Chromatin-modifying protein 4b (CHMP4b),RGD1309846,RGD1565889,SNF7,SNF7 homolog associated with Alix 1,SNF7-2,SNF7-2 (hSnf7-2),Shax1,Snf7-2,VPS32B,Vacuolar protein sorting-associated protein 32-2 (Vps32-2,Vps32-2,dJ553F4.4,hVps32-2)

Target products collectionGo to CHMP4B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T47731-Ag-1/ GM-Tg-hg-T47731-Ag-2 Human CHMP4B protein Human
GM-Tg-rg-T47731-Ag-1/ GM-Tg-rg-T47731-Ag-2 Rat CHMP4B protein Rat
GM-Tg-mg-T47731-Ag-1/ GM-Tg-mg-T47731-Ag-2 Mouse CHMP4B protein Mouse
GM-Tg-cynog-T47731-Ag-1/ GM-Tg-cynog-T47731-Ag-2 Cynomolgus/Rhesus macaque CHMP4B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T47731-Ag-1/ GM-Tg-felg-T47731-Ag-2 Feline CHMP4B protein Feline
GM-Tg-cang-T47731-Ag-1/ GM-Tg-cang-T47731-Ag-2 Canine CHMP4B protein Canine
GM-Tg-bovg-T47731-Ag-1/ GM-Tg-bovg-T47731-Ag-2 Bovine CHMP4B protein Bovine
GM-Tg-equg-T47731-Ag-1/ GM-Tg-equg-T47731-Ag-2 Equine CHMP4B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T47731-Ag-1/ GM-Tg-hg-T47731-Ag-2; GM-Tg-rg-T47731-Ag-1/ GM-Tg-rg-T47731-Ag-2;
GM-Tg-mg-T47731-Ag-1/ GM-Tg-mg-T47731-Ag-2; GM-Tg-cynog-T47731-Ag-1/ GM-Tg-cynog-T47731-Ag-2;
GM-Tg-felg-T47731-Ag-1/ GM-Tg-felg-T47731-Ag-2; GM-Tg-cang-T47731-Ag-1/ GM-Tg-cang-T47731-Ag-2;
GM-Tg-bovg-T47731-Ag-1/ GM-Tg-bovg-T47731-Ag-2; GM-Tg-equg-T47731-Ag-1/ GM-Tg-equg-T47731-Ag-2
Products Name CHMP4B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CHMP4B
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHMP4B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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