Recombinant multi-species INPP5D protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine INPP5D protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
The Alternative Names of target: INPP5D,Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1,Inositol polyphosphate-5-phosphatase D, Inositol polyphosphate-5-phosphatase of 145 kDa (SIP-145), Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, SH2 domain-containing inositol 5'-phosphatase 1 (SH2 domain-containing inositol phosphatase 1, SHIP-1), p150Ship (hp51CN),SHIP,SHIP1,SHIP-1,hp51CN,SIP-145,p150Ship

Target products collectionGo to INPP5D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T46871-Ab-1/ GM-Tg-hg-T46871-Ab-2 Human INPP5D protein Human
GM-Tg-rg-T46871-Ab-1/ GM-Tg-rg-T46871-Ab-2 Rat INPP5D protein Rat
GM-Tg-mg-T46871-Ab-1/ GM-Tg-mg-T46871-Ab-2 Mouse INPP5D protein Mouse
GM-Tg-cynog-T46871-Ab-1/ GM-Tg-cynog-T46871-Ab-2 Cynomolgus/Rhesus macaque INPP5D monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T46871-Ab-1/ GM-Tg-felg-T46871-Ab-2 Feline INPP5D protein Feline
GM-Tg-cang-T46871-Ab-1/ GM-Tg-cang-T46871-Ab-2 Canine INPP5D protein Canine
GM-Tg-bovg-T46871-Ab-1/ GM-Tg-bovg-T46871-Ab-2 Bovine INPP5D protein Bovine
GM-Tg-equg-T46871-Ab-1/ GM-Tg-equg-T46871-Ab-2 Equine INPP5D protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T46871-Ab-1/ GM-Tg-hg-T46871-Ab-2; GM-Tg-rg-T46871-Ab-1/ GM-Tg-rg-T46871-Ab-2;
GM-Tg-mg-T46871-Ab-1/ GM-Tg-mg-T46871-Ab-2; GM-Tg-cynog-T46871-Ab-1/ GM-Tg-cynog-T46871-Ab-2;
GM-Tg-felg-T46871-Ab-1/ GM-Tg-felg-T46871-Ab-2; GM-Tg-cang-T46871-Ab-1/ GM-Tg-cang-T46871-Ab-2;
GM-Tg-bovg-T46871-Ab-1/ GM-Tg-bovg-T46871-Ab-2; GM-Tg-equg-T46871-Ab-1/ GM-Tg-equg-T46871-Ab-2
Products Name INPP5D protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name INPP5D
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine INPP5D protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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