Recombinant multi-species TRAIL/CD253/TNFSF10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TRAIL/CD253/TNFSF10 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
The Alternative Names of target: A330042I21Rik,APO-2L,APO2L,Apo-2 ligand (Apo-2L),Apo-2L,CD253,Ly81,TANCR,TL2,TNF-related apoptosis-inducing ligand (Protein TRAIL),TNFSF10,TNLG6A,TRAIL,Tnfsf10,Tnlg6a,Trail,Tumor necrosis factor ligand superfamily member 10

Target products collectionGo to TRAIL/CD253/TNFSF10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T46084-Ag-1/ GM-Tg-hg-T46084-Ag-2 Human TRAIL/CD253/TNFSF10 protein Human
GM-Tg-rg-T46084-Ag-1/ GM-Tg-rg-T46084-Ag-2 Rat TRAIL/CD253/TNFSF10 protein Rat
GM-Tg-mg-T46084-Ag-1/ GM-Tg-mg-T46084-Ag-2 Mouse TRAIL/CD253/TNFSF10 protein Mouse
GM-Tg-cynog-T46084-Ag-1/ GM-Tg-cynog-T46084-Ag-2 Cynomolgus/Rhesus macaque TRAIL/CD253/TNFSF10 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T46084-Ag-1/ GM-Tg-felg-T46084-Ag-2 Feline TRAIL/CD253/TNFSF10 protein Feline
GM-Tg-cang-T46084-Ag-1/ GM-Tg-cang-T46084-Ag-2 Canine TRAIL/CD253/TNFSF10 protein Canine
GM-Tg-bovg-T46084-Ag-1/ GM-Tg-bovg-T46084-Ag-2 Bovine TRAIL/CD253/TNFSF10 protein Bovine
GM-Tg-equg-T46084-Ag-1/ GM-Tg-equg-T46084-Ag-2 Equine TRAIL/CD253/TNFSF10 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T46084-Ag-1/ GM-Tg-hg-T46084-Ag-2; GM-Tg-rg-T46084-Ag-1/ GM-Tg-rg-T46084-Ag-2;
GM-Tg-mg-T46084-Ag-1/ GM-Tg-mg-T46084-Ag-2; GM-Tg-cynog-T46084-Ag-1/ GM-Tg-cynog-T46084-Ag-2;
GM-Tg-felg-T46084-Ag-1/ GM-Tg-felg-T46084-Ag-2; GM-Tg-cang-T46084-Ag-1/ GM-Tg-cang-T46084-Ag-2;
GM-Tg-bovg-T46084-Ag-1/ GM-Tg-bovg-T46084-Ag-2; GM-Tg-equg-T46084-Ag-1/ GM-Tg-equg-T46084-Ag-2
Products Name TRAIL/CD253/TNFSF10 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TRAIL/CD253/TNFSF10
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TRAIL/CD253/TNFSF10 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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