Recombinant multi-species ALDH2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ALDH2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016]
The Alternative Names of target: AHD-M1,ALDH class 2,ALDH-E2,ALDH2,ALDHI,ALDM,Ahd-5,Ahd5,Aldehyde dehydrogenase,Aldh2,mitochondrial

Target products collectionGo to ALDH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T44282-Ag-1/ GM-Tg-hg-T44282-Ag-2 Human ALDH2 protein Human
GM-Tg-rg-T44282-Ag-1/ GM-Tg-rg-T44282-Ag-2 Rat ALDH2 protein Rat
GM-Tg-mg-T44282-Ag-1/ GM-Tg-mg-T44282-Ag-2 Mouse ALDH2 protein Mouse
GM-Tg-cynog-T44282-Ag-1/ GM-Tg-cynog-T44282-Ag-2 Cynomolgus/Rhesus macaque ALDH2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T44282-Ag-1/ GM-Tg-felg-T44282-Ag-2 Feline ALDH2 protein Feline
GM-Tg-cang-T44282-Ag-1/ GM-Tg-cang-T44282-Ag-2 Canine ALDH2 protein Canine
GM-Tg-bovg-T44282-Ag-1/ GM-Tg-bovg-T44282-Ag-2 Bovine ALDH2 protein Bovine
GM-Tg-equg-T44282-Ag-1/ GM-Tg-equg-T44282-Ag-2 Equine ALDH2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T44282-Ag-1/ GM-Tg-hg-T44282-Ag-2; GM-Tg-rg-T44282-Ag-1/ GM-Tg-rg-T44282-Ag-2;
GM-Tg-mg-T44282-Ag-1/ GM-Tg-mg-T44282-Ag-2; GM-Tg-cynog-T44282-Ag-1/ GM-Tg-cynog-T44282-Ag-2;
GM-Tg-felg-T44282-Ag-1/ GM-Tg-felg-T44282-Ag-2; GM-Tg-cang-T44282-Ag-1/ GM-Tg-cang-T44282-Ag-2;
GM-Tg-bovg-T44282-Ag-1/ GM-Tg-bovg-T44282-Ag-2; GM-Tg-equg-T44282-Ag-1/ GM-Tg-equg-T44282-Ag-2
Products Name ALDH2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ALDH2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ALDH2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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