Recombinant multi-species HSD17B1/17-beta-HSD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HSD17B1/17-beta-HSD1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
The Alternative Names of target: 17-beta-HSD,17-beta-HSD 1,17-beta-HSD1,17-beta-hydroxysteroid dehydrogenase type 1,17BHD1,17HSDB1,17beta-HSD,20 alpha-hydroxysteroid dehydrogenase (20-alpha-HSD),20-alpha-HSD,E2DH,EDH17B2,EDHB17,Estradiol 17-beta-dehydrogenase 1,HSD17,HSD17B1,Hsd17b1,Hsd17ba,Placental 17-beta-hydroxysteroid dehydrogenase,SDR28C1,Short chain dehydrogenase/reductase family 28C member 1

Target products collectionGo to HSD17B1/17-beta-HSD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T44011-Ag-1/ GM-Tg-hg-T44011-Ag-2 Human HSD17B1/17-beta-HSD1 protein Human
GM-Tg-rg-T44011-Ag-1/ GM-Tg-rg-T44011-Ag-2 Rat HSD17B1/17-beta-HSD1 protein Rat
GM-Tg-mg-T44011-Ag-1/ GM-Tg-mg-T44011-Ag-2 Mouse HSD17B1/17-beta-HSD1 protein Mouse
GM-Tg-cynog-T44011-Ag-1/ GM-Tg-cynog-T44011-Ag-2 Cynomolgus/Rhesus macaque HSD17B1/17-beta-HSD1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T44011-Ag-1/ GM-Tg-felg-T44011-Ag-2 Feline HSD17B1/17-beta-HSD1 protein Feline
GM-Tg-cang-T44011-Ag-1/ GM-Tg-cang-T44011-Ag-2 Canine HSD17B1/17-beta-HSD1 protein Canine
GM-Tg-bovg-T44011-Ag-1/ GM-Tg-bovg-T44011-Ag-2 Bovine HSD17B1/17-beta-HSD1 protein Bovine
GM-Tg-equg-T44011-Ag-1/ GM-Tg-equg-T44011-Ag-2 Equine HSD17B1/17-beta-HSD1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T44011-Ag-1/ GM-Tg-hg-T44011-Ag-2; GM-Tg-rg-T44011-Ag-1/ GM-Tg-rg-T44011-Ag-2;
GM-Tg-mg-T44011-Ag-1/ GM-Tg-mg-T44011-Ag-2; GM-Tg-cynog-T44011-Ag-1/ GM-Tg-cynog-T44011-Ag-2;
GM-Tg-felg-T44011-Ag-1/ GM-Tg-felg-T44011-Ag-2; GM-Tg-cang-T44011-Ag-1/ GM-Tg-cang-T44011-Ag-2;
GM-Tg-bovg-T44011-Ag-1/ GM-Tg-bovg-T44011-Ag-2; GM-Tg-equg-T44011-Ag-1/ GM-Tg-equg-T44011-Ag-2
Products Name HSD17B1/17-beta-HSD1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HSD17B1/17-beta-HSD1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HSD17B1/17-beta-HSD1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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