Recombinant multi-species IL-1 Beta/IL1B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-1 Beta/IL1B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]
The Alternative Names of target: Catabolin,IL-1,IL-1 Beta,IL-1 beta,IL-1F2,IL-1beta,IL1-BETA,IL1B,IL1F2,IL1beta,Il-1b,Il1b,Interleukin-1 beta

Target products collectionGo to IL-1 Beta/IL1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T42000-Ag-1/ GM-Tg-hg-T42000-Ag-2 Human IL-1 Beta/IL1B protein Human
GM-Tg-rg-T42000-Ag-1/ GM-Tg-rg-T42000-Ag-2 Rat IL-1 Beta/IL1B protein Rat
GM-Tg-mg-T42000-Ag-1/ GM-Tg-mg-T42000-Ag-2 Mouse IL-1 Beta/IL1B protein Mouse
GM-Tg-cynog-T42000-Ag-1/ GM-Tg-cynog-T42000-Ag-2 Cynomolgus/Rhesus macaque IL-1 Beta/IL1B protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T42000-Ag-1/ GM-Tg-felg-T42000-Ag-2 Feline IL-1 Beta/IL1B protein Feline
GM-Tg-cang-T42000-Ag-1/ GM-Tg-cang-T42000-Ag-2 Canine IL-1 Beta/IL1B protein Canine
GM-Tg-bovg-T42000-Ag-1/ GM-Tg-bovg-T42000-Ag-2 Bovine IL-1 Beta/IL1B protein Bovine
GM-Tg-equg-T42000-Ag-1/ GM-Tg-equg-T42000-Ag-2 Equine IL-1 Beta/IL1B protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T42000-Ag-1/ GM-Tg-hg-T42000-Ag-2; GM-Tg-rg-T42000-Ag-1/ GM-Tg-rg-T42000-Ag-2;
GM-Tg-mg-T42000-Ag-1/ GM-Tg-mg-T42000-Ag-2; GM-Tg-cynog-T42000-Ag-1/ GM-Tg-cynog-T42000-Ag-2;
GM-Tg-felg-T42000-Ag-1/ GM-Tg-felg-T42000-Ag-2; GM-Tg-cang-T42000-Ag-1/ GM-Tg-cang-T42000-Ag-2;
GM-Tg-bovg-T42000-Ag-1/ GM-Tg-bovg-T42000-Ag-2; GM-Tg-equg-T42000-Ag-1/ GM-Tg-equg-T42000-Ag-2
Products Name IL-1 Beta/IL1B protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-1 Beta/IL1B
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-1 Beta/IL1B protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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