Recombinant multi-species ELA2/ELANE/NE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ELA2/ELANE/NE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
The Alternative Names of target: Bone marrow serine protease,ELA2,ELANE,Ela2,Elane,Elastase-2,F430011M15Rik,GE,HLE,HNE,Human leukocyte elastase (HLE),Medullasin,NE,Neutrophil elastase,PMN elastase,PMN-E,SCN1

Target products collectionGo to ELA2/ELANE/NE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T40332-Ag-1/ GM-Tg-hg-T40332-Ag-2 Human ELA2/ELANE/NE protein Human
GM-Tg-rg-T40332-Ag-1/ GM-Tg-rg-T40332-Ag-2 Rat ELA2/ELANE/NE protein Rat
GM-Tg-mg-T40332-Ag-1/ GM-Tg-mg-T40332-Ag-2 Mouse ELA2/ELANE/NE protein Mouse
GM-Tg-cynog-T40332-Ag-1/ GM-Tg-cynog-T40332-Ag-2 Cynomolgus/Rhesus macaque ELA2/ELANE/NE protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T40332-Ag-1/ GM-Tg-felg-T40332-Ag-2 Feline ELA2/ELANE/NE protein Feline
GM-Tg-cang-T40332-Ag-1/ GM-Tg-cang-T40332-Ag-2 Canine ELA2/ELANE/NE protein Canine
GM-Tg-bovg-T40332-Ag-1/ GM-Tg-bovg-T40332-Ag-2 Bovine ELA2/ELANE/NE protein Bovine
GM-Tg-equg-T40332-Ag-1/ GM-Tg-equg-T40332-Ag-2 Equine ELA2/ELANE/NE protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T40332-Ag-1/ GM-Tg-hg-T40332-Ag-2; GM-Tg-rg-T40332-Ag-1/ GM-Tg-rg-T40332-Ag-2;
GM-Tg-mg-T40332-Ag-1/ GM-Tg-mg-T40332-Ag-2; GM-Tg-cynog-T40332-Ag-1/ GM-Tg-cynog-T40332-Ag-2;
GM-Tg-felg-T40332-Ag-1/ GM-Tg-felg-T40332-Ag-2; GM-Tg-cang-T40332-Ag-1/ GM-Tg-cang-T40332-Ag-2;
GM-Tg-bovg-T40332-Ag-1/ GM-Tg-bovg-T40332-Ag-2; GM-Tg-equg-T40332-Ag-1/ GM-Tg-equg-T40332-Ag-2
Products Name ELA2/ELANE/NE protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ELA2/ELANE/NE
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ELA2/ELANE/NE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.