Recombinant multi-species P21/CDKN1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P21/CDKN1A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
The Alternative Names of target: CAP20,CDK-interacting protein 1,CDKI,CDKN1,CDKN1A,CIP1,Cdkn1,Cdkn1a,Cip1,Cyclin-dependent kinase inhibitor 1,MDA-6,Melanoma differentiation-associated protein 6 (MDA-6),P21,SDI1,UV96,WAF1,Waf1,mda6,p21,p21CIP1,p21Cip1,p21WAF

Target products collectionGo to P21/CDKN1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T39855-Ag-1/ GM-Tg-hg-T39855-Ag-2 Human P21/CDKN1A protein Human
GM-Tg-rg-T39855-Ag-1/ GM-Tg-rg-T39855-Ag-2 Rat P21/CDKN1A protein Rat
GM-Tg-mg-T39855-Ag-1/ GM-Tg-mg-T39855-Ag-2 Mouse P21/CDKN1A protein Mouse
GM-Tg-cynog-T39855-Ag-1/ GM-Tg-cynog-T39855-Ag-2 Cynomolgus/Rhesus macaque P21/CDKN1A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T39855-Ag-1/ GM-Tg-felg-T39855-Ag-2 Feline P21/CDKN1A protein Feline
GM-Tg-cang-T39855-Ag-1/ GM-Tg-cang-T39855-Ag-2 Canine P21/CDKN1A protein Canine
GM-Tg-bovg-T39855-Ag-1/ GM-Tg-bovg-T39855-Ag-2 Bovine P21/CDKN1A protein Bovine
GM-Tg-equg-T39855-Ag-1/ GM-Tg-equg-T39855-Ag-2 Equine P21/CDKN1A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T39855-Ag-1/ GM-Tg-hg-T39855-Ag-2; GM-Tg-rg-T39855-Ag-1/ GM-Tg-rg-T39855-Ag-2;
GM-Tg-mg-T39855-Ag-1/ GM-Tg-mg-T39855-Ag-2; GM-Tg-cynog-T39855-Ag-1/ GM-Tg-cynog-T39855-Ag-2;
GM-Tg-felg-T39855-Ag-1/ GM-Tg-felg-T39855-Ag-2; GM-Tg-cang-T39855-Ag-1/ GM-Tg-cang-T39855-Ag-2;
GM-Tg-bovg-T39855-Ag-1/ GM-Tg-bovg-T39855-Ag-2; GM-Tg-equg-T39855-Ag-1/ GM-Tg-equg-T39855-Ag-2
Products Name P21/CDKN1A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name P21/CDKN1A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine P21/CDKN1A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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