Recombinant multi-species MDMX/MDM4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MDMX/MDM4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
The Alternative Names of target: 4933417N07Rik,BMFS6,Double minute 4 protein,HDMX,MDM4,MDMX,MRP1,Mdm2-like p53-binding protein,Mdm4,Mdmx,Protein Mdm4,Protein Mdmx,p53-binding protein Mdm4

Target products collectionGo to MDMX/MDM4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T36741-Ag-1/ GM-Tg-hg-T36741-Ag-2 Human MDMX/MDM4 protein Human
GM-Tg-rg-T36741-Ag-1/ GM-Tg-rg-T36741-Ag-2 Rat MDMX/MDM4 protein Rat
GM-Tg-mg-T36741-Ag-1/ GM-Tg-mg-T36741-Ag-2 Mouse MDMX/MDM4 protein Mouse
GM-Tg-cynog-T36741-Ag-1/ GM-Tg-cynog-T36741-Ag-2 Cynomolgus/Rhesus macaque MDMX/MDM4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T36741-Ag-1/ GM-Tg-felg-T36741-Ag-2 Feline MDMX/MDM4 protein Feline
GM-Tg-cang-T36741-Ag-1/ GM-Tg-cang-T36741-Ag-2 Canine MDMX/MDM4 protein Canine
GM-Tg-bovg-T36741-Ag-1/ GM-Tg-bovg-T36741-Ag-2 Bovine MDMX/MDM4 protein Bovine
GM-Tg-equg-T36741-Ag-1/ GM-Tg-equg-T36741-Ag-2 Equine MDMX/MDM4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T36741-Ag-1/ GM-Tg-hg-T36741-Ag-2; GM-Tg-rg-T36741-Ag-1/ GM-Tg-rg-T36741-Ag-2;
GM-Tg-mg-T36741-Ag-1/ GM-Tg-mg-T36741-Ag-2; GM-Tg-cynog-T36741-Ag-1/ GM-Tg-cynog-T36741-Ag-2;
GM-Tg-felg-T36741-Ag-1/ GM-Tg-felg-T36741-Ag-2; GM-Tg-cang-T36741-Ag-1/ GM-Tg-cang-T36741-Ag-2;
GM-Tg-bovg-T36741-Ag-1/ GM-Tg-bovg-T36741-Ag-2; GM-Tg-equg-T36741-Ag-1/ GM-Tg-equg-T36741-Ag-2
Products Name MDMX/MDM4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MDMX/MDM4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MDMX/MDM4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.