Recombinant multi-species WT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
The Alternative Names of target: AWT1,D630046I19Rik,GUD,NPHS4,WAGR,WIT-2,WT,WT-1,WT1,WT33,Wilms tumor protein,Wt-1,Wt1

Target products collectionGo to WT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T29960-Ag-1/ GM-Tg-hg-T29960-Ag-2 Human WT1 protein Human
GM-Tg-rg-T29960-Ag-1/ GM-Tg-rg-T29960-Ag-2 Rat WT1 protein Rat
GM-Tg-mg-T29960-Ag-1/ GM-Tg-mg-T29960-Ag-2 Mouse WT1 protein Mouse
GM-Tg-cynog-T29960-Ag-1/ GM-Tg-cynog-T29960-Ag-2 Cynomolgus/Rhesus macaque WT1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T29960-Ag-1/ GM-Tg-felg-T29960-Ag-2 Feline WT1 protein Feline
GM-Tg-cang-T29960-Ag-1/ GM-Tg-cang-T29960-Ag-2 Canine WT1 protein Canine
GM-Tg-bovg-T29960-Ag-1/ GM-Tg-bovg-T29960-Ag-2 Bovine WT1 protein Bovine
GM-Tg-equg-T29960-Ag-1/ GM-Tg-equg-T29960-Ag-2 Equine WT1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T29960-Ag-1/ GM-Tg-hg-T29960-Ag-2; GM-Tg-rg-T29960-Ag-1/ GM-Tg-rg-T29960-Ag-2;
GM-Tg-mg-T29960-Ag-1/ GM-Tg-mg-T29960-Ag-2; GM-Tg-cynog-T29960-Ag-1/ GM-Tg-cynog-T29960-Ag-2;
GM-Tg-felg-T29960-Ag-1/ GM-Tg-felg-T29960-Ag-2; GM-Tg-cang-T29960-Ag-1/ GM-Tg-cang-T29960-Ag-2;
GM-Tg-bovg-T29960-Ag-1/ GM-Tg-bovg-T29960-Ag-2; GM-Tg-equg-T29960-Ag-1/ GM-Tg-equg-T29960-Ag-2
Products Name WT1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name WT1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WT1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.