Recombinant multi-species RUNX3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RUNX3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
The Alternative Names of target: RUNX3,Runt-related transcription factor 3,Acute myeloid leukemia 2 protein, Core-binding factor subunit alpha-3 (CBF-alpha-3), Oncogene AML-2, Polyomavirus enhancer-binding protein 2 alpha C subunit (PEA2-alpha C, PEBP2-alpha C), SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit,AML2,CBFA3,PEBP2aC

Target products collectionGo to RUNX3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T29630-Ab-1/ GM-Tg-hg-T29630-Ab-2 Human RUNX3 protein Human
GM-Tg-rg-T29630-Ab-1/ GM-Tg-rg-T29630-Ab-2 Rat RUNX3 protein Rat
GM-Tg-mg-T29630-Ab-1/ GM-Tg-mg-T29630-Ab-2 Mouse RUNX3 protein Mouse
GM-Tg-cynog-T29630-Ab-1/ GM-Tg-cynog-T29630-Ab-2 Cynomolgus/Rhesus macaque RUNX3 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T29630-Ab-1/ GM-Tg-felg-T29630-Ab-2 Feline RUNX3 protein Feline
GM-Tg-cang-T29630-Ab-1/ GM-Tg-cang-T29630-Ab-2 Canine RUNX3 protein Canine
GM-Tg-bovg-T29630-Ab-1/ GM-Tg-bovg-T29630-Ab-2 Bovine RUNX3 protein Bovine
GM-Tg-equg-T29630-Ab-1/ GM-Tg-equg-T29630-Ab-2 Equine RUNX3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T29630-Ab-1/ GM-Tg-hg-T29630-Ab-2; GM-Tg-rg-T29630-Ab-1/ GM-Tg-rg-T29630-Ab-2;
GM-Tg-mg-T29630-Ab-1/ GM-Tg-mg-T29630-Ab-2; GM-Tg-cynog-T29630-Ab-1/ GM-Tg-cynog-T29630-Ab-2;
GM-Tg-felg-T29630-Ab-1/ GM-Tg-felg-T29630-Ab-2; GM-Tg-cang-T29630-Ab-1/ GM-Tg-cang-T29630-Ab-2;
GM-Tg-bovg-T29630-Ab-1/ GM-Tg-bovg-T29630-Ab-2; GM-Tg-equg-T29630-Ab-1/ GM-Tg-equg-T29630-Ab-2
Products Name RUNX3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RUNX3
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RUNX3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.